On the Formation of Digits and Joints during Limb Development.

Hiscock TW; Tschopp P; Tabin CJ

doi:10.1016/j.devcel.2017.04.021

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Journal article

On the Formation of Digits and Joints during Limb Development.

Hiscock TW Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Tschopp P Zoological Institute, University of Basel, 4051 Basel, Switzerland.
Tabin CJ Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Electronic address: tabin@genetics.med.harvard.edu.

2017-06-07

Published in:

Developmental cell. - 2017

English Critical steps in forming the vertebrate limb include the positioning of digits and the positioning of joints within each digit. Recent studies have proposed that the iterative series of digits is established by a Turing-like mechanism generating stripes of chondrogenic domains. However, re-examination of available data suggest that digits are actually patterned as evenly spaced spots, not stripes, which then elongate into rod-shaped digit rays by incorporating new cells at their tips. Moreover, extension of the digit rays and the patterning of the joints occur simultaneously at the distal tip, implying that an integrated model is required to fully understand these processes.

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