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How Somatic Adult Tissues Develop Organizer Activity.
Journal article

How Somatic Adult Tissues Develop Organizer Activity.

  • Vogg MC Department of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (IGe3), Faculty of Sciences, University of Geneva, Geneva, Switzerland.
  • Wenger Y Department of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (IGe3), Faculty of Sciences, University of Geneva, Geneva, Switzerland.
  • Galliot B Department of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (IGe3), Faculty of Sciences, University of Geneva, Geneva, Switzerland. Electronic address: brigitte.galliot@unige.ch.
  • 2016-03-13
Published in:
  • Current topics in developmental biology. - 2016
Adult tissues
Blastema
De novo organizer formation
Homeostasis
Hydra
Model systems
Planaria
Regeneration
Wnt signaling
Adult
Animals
Body Patterning
Cell Differentiation
Gene Expression Regulation, Developmental
Humans
Hydra
Organizers, Embryonic
Planarians
Regeneration
Signal Transduction
Wnt Proteins
English The growth and patterning of anatomical structures from specific cellular fields in developing organisms relies on organizing centers that instruct surrounding cells to modify their behavior, namely migration, proliferation, and differentiation. We discuss here how organizers can form in adult organisms, a process of utmost interest for regenerative medicine. Animals like Hydra and planarians, which maintain their shape and fitness thanks to a highly dynamic homeostasis, offer a useful paradigm to study adult organizers in steady-state conditions. Beside the homeostatic context, these model systems also offer the possibility to study how organizers form de novo from somatic adult tissues. Both extracellular matrix remodeling and caspase activation play a key role in this transition, acting as promoters of organizer formation in the vicinity of the wound. Their respective roles and the crosstalk between them just start to be deciphered.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/232423
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