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Interplay between midbrain and dorsal anterior cingulate regions arbitrates lingering reward effects on memory encoding.

  • Aberg KC Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel. kc.aberg@gmail.com.
  • Kramer EE Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, Canada.
  • Schwartz S Department of Neuroscience, University of Geneva, Geneva, Switzerland.
  • 2020-04-15
Published in:
  • Nature communications. - 2020
Adult
Behavior
Feedback
Female
Gyrus Cinguli
Humans
Male
Memory
Mesencephalon
Nerve Net
Nonlinear Dynamics
Oxygen
Photic Stimulation
Reward
Ventral Tegmental Area
English Rewarding events enhance memory encoding via dopaminergic influences on hippocampal plasticity. Phasic dopamine release depends on immediate reward magnitude, but presumably also on tonic dopamine levels, which may vary as a function of the average accumulation of reward over time. Using model-based fMRI in combination with a novel associative memory task, we show that immediate reward magnitude exerts a monotonically increasing influence on the nucleus accumbens, ventral tegmental area (VTA), and hippocampal activity during encoding, and enhances memory. By contrast, average reward levels modulate feedback-related responses in the VTA and hippocampus in a non-linear (inverted U-shape) fashion, with similar effects on memory performance. Additionally, the dorsal anterior cingulate cortex (dACC) monotonically tracks average reward levels, while VTA-dACC functional connectivity is non-linearly modulated (inverted U-shape) by average reward. We propose that the dACC computes the net behavioral impact of average reward and relays this information to memory circuitry via the VTA.
Language
  • English
Open access status
gold
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Persistent URL
https://sonar.ch/global/documents/232876
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