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Heavy drinking habits are associated with worse in-hospital outcomes in patients with acute coronary syndrome
Journal article

Heavy drinking habits are associated with worse in-hospital outcomes in patients with acute coronary syndrome

  • Tersalvi, G Cardiocentro Ticino, Department of Cardiology, Lugano, Switzerland
  • Biasco, L University of Italian Switzerland, Department of Biomedical Sciences, Lugano, Switzerland
  • Radovanovic, D University of Zurich, AMIS Plus Data Center, Epidemiology, Biostatistics and Prevention Institute, Zurich, Switzerland
  • Rickli, H Kantonsspital St. Gallen, Department of Cardiology, St. Gallen, Switzerland
  • Roffi, M University Hospital of Geneva, Department of Cardiology, Geneva, Switzerland
  • Eberli, F Triemli Hospital, Department of Cardiology, Zurich, Switzerland
  • Moccetti, M Cardiocentro Ticino, Department of Cardiology, Lugano, Switzerland
  • Jeger, R University Hospital Basel, Department of Cardiology, Basel, Switzerland
  • Moccetti, T Cardiocentro Ticino, Department of Cardiology, Lugano, Switzerland
  • Erne, P University of Zurich, AMIS Plus Data Center, Epidemiology, Biostatistics and Prevention Institute, Zurich, Switzerland
  • Pedrazzini, G.B Cardiocentro Ticino, Department of Cardiology, Lugano, Switzerland
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  • 2020-11-25
Published in:
  • European Heart Journal. - Oxford University Press (OUP). - 2020, vol. 41, no. Supplement_2
Cardiology and Cardiovascular Medicine
English Abstract

Introduction
The association between alcohol consumption and the occurrence of coronary heart disease is well described in literature. Data regarding the impact of regular alcohol consumption on in-hospital outcomes in the setting of acute coronary syndrome (ACS) are lacking.


Purpose
We aimed to evaluate the impact of self-reported alcohol consumption on in-hospital outcomes in patients with ACS.


Methods
Data derived from patients enrolled between 2007 and 2019 in the Acute Myocardial Infarction in Switzerland (AMIS) Plus registry were retrospectively analyzed. The primary endpoint was all-cause in-hospital mortality, while secondary endpoints were set as incidence of major adverse cardiac and cerebrovascular events (MACCEs). Outcomes comparisons according to quantity of daily alcohol intake were also performed.


Results
Records concerning alcohol consumption were available in 25707 patients; 5298 of them (21%) fulfilled the criteria of regular alcohol consumption. Daily alcohol intake was reported in 4059 (77%), of these patients (regular drinkers) with 2640 light drinkers (≤2 drinks/day) and 1419 heavy drinkers (>2 drinks/day). Regular drinkers were predominantly male, younger, smokers, more comorbid and with a worse clinical presentation as compared to abstainers/occasional drinkers.
In-hospital mortality and MACCEs of heavy drinkers were significantly higher compared to light drinkers (5.4% vs. 3.3% and 7.0% vs. 4.4%, both p=0.001). When tested together with GRACE risk score parameters, heavy alcohol consumption was independently associated to in-hospital mortality (p=0.004).


Conclusions
Heavy alcohol consumption is an additional independent predictor of in-hospital mortality in patients presenting with ACS.
Figure 1. Study flowchart.


Funding Acknowledgement
Type of funding source: Other. Main funding source(s): Swiss Heart Foundation
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/235776
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