Journal article
Pathology induced by leukemia inhibitory factor.
- Ryffel B Institut für Toxikologie, Eidgenössischen Technischen Hochschule Universität Zürich, Switzerland.
- 1993-01-01
Published in:
- International review of experimental pathology. - 1993
Acute-Phase Reaction
Animals
Cachexia
Calcinosis
Growth Inhibitors
Interleukin-6
Leukemia Inhibitory Factor
Lymphokines
Macaca mulatta
Mice
Osteoblasts
Recombinant Proteins
Species Specificity
English
Leukemia inhibitory factor is a glycoprotein growth and differentiation factor with pleiotropic activity. LIF has potent effects on the hematopoietic system, including megakaryocyte progenitor cells. In addition, LIF has bone regeneration activity, induces cachexia and acute-phase response in hepatocytes, and inhibits adipogenesis, to mention the more important activities. In vivo LIF treatment in monkeys and rodents was followed by signs of general toxicity, cachexia, acute-phase reaction, and stimulation of hematopoiesis. The safety margin for possible therapeutic effects on hematopoiesis seems to be very narrow.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/b978-0-12-364935-5.50010-9
- PMID 8458718
- Persistent URL
- https://sonar.ch/global/documents/237717
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