The catalytic mechanism of sulfoxide synthases.

Stampfli AR; Seebeck FP

doi:10.1016/j.cbpa.2020.06.007

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Journal article

The catalytic mechanism of sulfoxide synthases.

Stampfli AR Department for Chemistry, University of Basel, BPR 1096, Mattenstrasse 24a, Basel, Switzerland.
Seebeck FP Department for Chemistry, University of Basel, BPR 1096, Mattenstrasse 24a, Basel, Switzerland. Electronic address: florian.seebeck@unibas.ch.

2020-07-30

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Current opinion in chemical biology. - 2020

English Sulfoxide synthases are non-heme iron enzymes that catalyze oxidative carbonsulfur bond formation in the biosynthesis of thiohistidines such as ergothioneine and ovothiol. The catalytic mechanism of these enzymes has been studied by protein crystallography, steady-state kinetics, non-natural amino acid incorporation and computational modeling. This review discusses the current status of this research and also highlights similarities between the CS bond forming activity of sulfoxide synthases with that of synthetic coordination compounds.

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