Mechanisms of replication origin licensing: a structural perspective.

Bleichert F

doi:10.1016/j.sbi.2019.08.007

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Journal article

Mechanisms of replication origin licensing: a structural perspective.

Bleichert F Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland. Electronic address: franziska.bleichert@fmi.ch.

2019-10-21

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Current opinion in structural biology. - 2019

Quantitative Structure-Activity Relationship

English The duplication of chromosomal DNA is a key cell cycle event that involves the controlled, bidirectional assembly of the replicative machinery. In a tightly regulated, multi-step reaction, replicative helicases and other components of the DNA synthesis apparatus are recruited to replication start sites. Although the molecular approaches for assembling this machinery vary between the different domains of life, a common theme revolves around the use of ATP-dependent initiation factors to recognize and remodel origins and to load replicative helicases in a bidirectional manner onto DNA. This review summarizes recent advances in understanding the mechanisms of replication initiation in eukaryotes, focusing on how the replicative helicase is loaded in this system.

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