Journal article
REM sleep without atonia with REM sleep-related motor events: broadening the spectrum of REM sleep behavior disorder.
- Ferri R Oasi Research Institute - IRCCS, Troina, Italy.
- Aricò D Oasi Research Institute - IRCCS, Troina, Italy.
- Cosentino FII Oasi Research Institute - IRCCS, Troina, Italy.
- Lanuzza B Oasi Research Institute - IRCCS, Troina, Italy.
- Chiaro G Sleep and Epilepsy Center, Neurocenter of Southern Switzerland, Civic Hospital (EOC) of Lugano, Lugano, Switzerland.
- Manconi M Sleep and Epilepsy Center, Neurocenter of Southern Switzerland, Civic Hospital (EOC) of Lugano, Lugano, Switzerland.
- 2018-09-22
Published in:
- Sleep. - 2018
Aged
Female
Hong Kong
Humans
Male
Middle Aged
Motor Activity
Muscle Hypotonia
Polysomnography
REM Sleep Behavior Disorder
Sleep, REM
Surveys and Questionnaires
Video Recording
English
Study Objectives
To assess the presence of increased REM-related motor activity during sleep, by questionnaires for REM sleep behavior disorder (RBD), in participants with "isolated" REM sleep without atonia (RWA).
Participants and Methods
Two hundred forty-nine patients were consecutively enrolled, with age ≥18 years, sharing bedroom with a roommate, and without a severe health, neurological, or cognitive problem. Motor activity during sleep was assessed by means of the RBD Screening Questionnaire (RBDSQ) and the RBD questionnaire-Hong Kong (RBDQ-HK). A video-polysomnographic recording was obtained and the REM Atonia Index was computed. Thirteen participants were diagnosed to have RBD while the remaining 236 were subdivided into two subgroups: 34 participants with "low" (<0.8) and 202 participants with "high" Atonia Index (≥0.8).
Results
RBDSQ and RBDQ-HK were both higher in participants with low Atonia Index than in those with high Atonia Index, as well as number of drugs taken and number of comorbidities. No effect of antidepressant use was found on Atonia Index and a multiple-regression analysis showed that Atonia Index was significantly (inversely) correlated only with the behavioral score obtained with the RBDQ-HK.
Conclusions
Our study shows that individuals with isolated RWA have an increased motor activity/behavioral pattern during sleep, although this activity does not allow us to diagnose RBD. Our findings broaden the spectrum of RBD and the condition that we have identified should be better characterized in order to understand its eventual development into fully blown RBD or not.
To assess the presence of increased REM-related motor activity during sleep, by questionnaires for REM sleep behavior disorder (RBD), in participants with "isolated" REM sleep without atonia (RWA).
Participants and Methods
Two hundred forty-nine patients were consecutively enrolled, with age ≥18 years, sharing bedroom with a roommate, and without a severe health, neurological, or cognitive problem. Motor activity during sleep was assessed by means of the RBD Screening Questionnaire (RBDSQ) and the RBD questionnaire-Hong Kong (RBDQ-HK). A video-polysomnographic recording was obtained and the REM Atonia Index was computed. Thirteen participants were diagnosed to have RBD while the remaining 236 were subdivided into two subgroups: 34 participants with "low" (<0.8) and 202 participants with "high" Atonia Index (≥0.8).
Results
RBDSQ and RBDQ-HK were both higher in participants with low Atonia Index than in those with high Atonia Index, as well as number of drugs taken and number of comorbidities. No effect of antidepressant use was found on Atonia Index and a multiple-regression analysis showed that Atonia Index was significantly (inversely) correlated only with the behavioral score obtained with the RBDQ-HK.
Conclusions
Our study shows that individuals with isolated RWA have an increased motor activity/behavioral pattern during sleep, although this activity does not allow us to diagnose RBD. Our findings broaden the spectrum of RBD and the condition that we have identified should be better characterized in order to understand its eventual development into fully blown RBD or not.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1093/sleep/zsy187
- PMID 30239958
- Persistent URL
- https://sonar.ch/global/documents/249221
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