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Journal article

Reproducibility of cerebral tissue oxygen saturation measurements by near-infrared spectroscopy in newborn infants.

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  • 2011-09-29
Published in:
  • Journal of biomedical optics. - 2011
Algorithms
Brain
Brain Chemistry
Female
Humans
Hypoxia, Brain
Infant, Newborn
Male
Oximetry
Oxygen
Reproducibility of Results
Spectroscopy, Near-Infrared
Statistics, Nonparametric
English Early detection of cerebral hypoxemia is an important aim in neonatology. A relevant parameter to assess brain oxygenation may be the cerebral tissue oxygen saturation (StO(2)) measured by near-infrared spectroscopy (NIRS). So far the reproducibility of StO(2) measurements was too low for clinical application, probably due to inhomogeneities. The aim of this study was to test a novel sensor geometry which reduces the influence of inhomogeneities. Thirty clinically stable newborn infants, with a gestational age of median 33.9 (range 26.9 to 41.9) weeks, birth weight of 2220 (820 to 4230) g, postnatal age of 5 (1 to 71) days were studied. At least four StO(2) measurements of 1 min duration were carried out using NIRS on the lateral head. The sensor was repositioned between measurements. Reproducibility was calculated by a linear mixed effects model. The mean StO(2) was 79.99 ± 4.47% with a reproducibility of 2.76% and a between-infant variability of 4.20%. Thus, the error of measurement only accounts for 30.1% of the variability. The novel sensor geometry leads to considerably more precise measurements compared to previous studies with, e.g., ∼5% reproducibility for the NIRO 300. The novel StO(2) values hence have a higher clinical relevance.
Language
  • English
Open access status
green
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Persistent URL
https://sonar.ch/global/documents/251693
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