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Modulating the Anticancer Activity of Ruthenium(II)-Arene Complexes.
Journal article

Modulating the Anticancer Activity of Ruthenium(II)-Arene Complexes.

  • Clavel CM †Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
  • Păunescu E †Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
  • Nowak-Sliwinska P †Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
  • Griffioen AW ‡Angiogenesis Laboratory, Department of Medical Oncology, VUMC Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands.
  • Scopelliti R †Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
  • Dyson PJ †Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
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  • 2015-03-27
Published in:
  • Journal of medicinal chemistry. - 2015
Angiogenesis Inhibitors
Animals
Antineoplastic Agents
Cell Line, Tumor
Cell Proliferation
Chick Embryo
Coordination Complexes
Crystallography, X-Ray
Cymenes
Humans
Models, Molecular
Monoterpenes
Neoplasms
Ruthenium
English Following the identification of [Ru(η(6)-p-cymene)Cl2(1H,1H,2H,2H-perfluorodecyl-3-(pyridin-3-yl)propanoate)], a ruthenium(II)-arene complex with a perfluoroalkyl-modified ligand that displays remarkable in vitro cancer cell selectivity, a series of structurally related compounds were designed. In the new derivatives, the p-cymene ring and/or the chloride ligands are substituted by other ligands to modulate the steric bulk or aquation kinetics. The new compounds were evaluated in both in vitro (cytotoxicity and migration assays) and in vivo (chicken chorioallantoic membrane) models and were found to exhibit potent antivascular effects.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/256511
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