Dependence of brain intravoxel incoherent motion perfusion parameters on the cardiac cycle.

Federau C; Hagmann P; Maeder P; Müller M; Meuli R; Stuber M; O'Brien K

doi:10.1371/journal.pone.0072856

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Journal article

Dependence of brain intravoxel incoherent motion perfusion parameters on the cardiac cycle.

Federau C Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne, Lausanne, Switzerland.
Hagmann P
Maeder P
Müller M
Meuli R
Stuber M
O'Brien K

2013-09-12

Published in:

PloS one. - 2013

Diffusion Magnetic Resonance Imaging

English Measurement of microvascular perfusion with Intravoxel Incoherent Motion (IVIM) MRI is gaining interest. Yet, the physiological influences on the IVIM perfusion parameters ("pseudo-diffusion" coefficient D*, perfusion fraction f, and flow related parameter fD*) remain insufficiently characterized. In this article, we hypothesize that D* and fD*, which depend on blood speed, should vary during the cardiac cycle. We extended the IVIM model to include time dependence of D* = D*(t), and demonstrate in the healthy human brain that both parameters D* and fD* are significantly larger during systole than diastole, while the diffusion coefficient D and f do not vary significantly. The results non-invasively demonstrate the pulsatility of the brain's microvasculature.

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