Journal article
Genetically modified mice and cognition.
- 1998-06-23
Published in:
- Current opinion in neurobiology. - 1998
Animals
Cognition
Humans
Maze Learning
Mice
Mice, Knockout
Mice, Transgenic
Nerve Growth Factors
Neural Cell Adhesion Molecules
Rats
Signal Transduction
Swimming
English
Cognition in transgenic and knockout mice is preferentially assessed by spatial learning in the Morris water maze. Awareness is growing, however, that the putative cognitive deficits observed using such a paradigm may be biased by the genetic background and behavioral peculiarities of the specific animals used. Recent progress in cognitive research includes new behavioral tests and refined analysis of performance impairments. Advances in our understanding of memory and learning are being made possible through use of transgenic rescue of disrupted genes, inducible and reversible gene targeting in selected brain regions, and single-cell recordings of hippocampal place cells in mutant mice.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/s0959-4388(98)80151-7
- PMID 9635213
- Persistent URL
- https://sonar.ch/global/documents/264819
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