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A genome-wide significant association on chromosome 2 for footrot resistance/susceptibility in Swiss White Alpine sheep.
Journal article

A genome-wide significant association on chromosome 2 for footrot resistance/susceptibility in Swiss White Alpine sheep.

  • Niggeler A Institute of Genetics, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, 3012, Bern, Switzerland.
  • Tetens J Division Functional Breeding, Department of Animal Sciences, Georg-August University, Burckhardtweg 2, 37077, Göttingen, Germany.
  • Stäuble A Clinic for Ruminants, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, 3012, Bern, Switzerland.
  • Steiner A Clinic for Ruminants, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, 3012, Bern, Switzerland.
  • Drögemüller C Institute of Genetics, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, 3012, Bern, Switzerland.
  • 2017-10-07
Published in:
  • Animal genetics. - 2017
Dichelobacter nodosus
GWAS
MPDZ
MUPP1
lameness
Animals
Carrier Proteins
Disease Resistance
Foot Rot
Genetic Predisposition to Disease
Genome-Wide Association Study
Hoof and Claw
Linear Models
Models, Genetic
Polymorphism, Single Nucleotide
Sheep
Sheep Diseases
English Footrot is one of the most important causes of lameness in global sheep populations and is characterized by a bacterial infection of the interdigital skin. As a multifactorial disease, its clinical representation depends not only on pathogen factors and environmental components but also on the individual resistance/susceptibility of the host. A genetic component has been shown in previous studies; however, so far no causative genetic variant influencing the risk of developing footrot has been identified. In this study, we genotyped 373 Swiss White Alpine sheep, using the ovine high-density 600k SNP chip, in order to run a DNA-based comparison of individuals with known clinical footrot status. We performed a case-control genome-wide association study, which revealed a genome-wide significant association for SNP rs418747104 on ovine chromosome 2 at 81.2 Mb. The three best associated SNP markers were located at the MPDZ gene, which codes for the multiple PDZ domain crumbs cell polarity complex component protein, also known as multi-PDZ domain protein 1 (MUPP1). This protein is possibly involved in maintaining the barrier function and integrity of tight junctions. Therefore, we speculate that individuals carrying MPDZ variants may differ in their footrot resistance/susceptibility due to modified horn and interdigital skin integrity. In conclusion, our study reveals that MPDZ might represent a functional candidate gene, and further research is needed to explore its role in footrot affected sheep.
Language
  • English
Open access status
closed
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Persistent URL
https://sonar.ch/global/documents/277
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