Journal article
Prognosis in Duke's B colorectal carcinoma: the Jass classification revisited.
- De Quay N Department of Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
- Cerottini JP
- Albe X
- Saraga E
- Givel JC
- Caplin S
- 1999-08-05
Published in:
- The European journal of surgery = Acta chirurgica. - 1999
Aged
Cohort Studies
Colorectal Neoplasms
Disease-Free Survival
Female
Humans
Male
Neoplasm Staging
Prognosis
English
OBJECTIVE
To assess whether Jass staging enhances prognostic prediction in Dukes' B colorectal carcinoma.
DESIGN
A historical cohort observational study.
SETTING
A university tertiary care centre, Switzerland.
SUBJECTS
108 consecutive patients.
INTERVENTIONS
Curative resection of Dukes' B colorectal carcinoma between January 1985 and December 1988, Patients with familial adenomatous polyposis; hereditary non-polyposis colorectal cancer; Crohns' disease; ulcerative colitis and synchronous and recurrent tumours were excluded. A comparable group of 155 consecutive patients with Dukes' C carcinoma were included for reference purposes.
MAIN OUTCOME MEASURES
Disease free and overall survival for Dukes' B and overall survival for Dukes' C tumours.
RESULTS
Dukes' B tumours in Jass group III or with an infiltrated margin had a significantly worse disease-free survival (p = 0.001 and 0.0001, respectively) and those with infiltrated margins had a significantly worse overall survival (p = 0.002). Overall survival among those with Dukes' B Jass III and Dukes' B with infiltrated margins was no better than overall survival among all patients with Dukes' C tumours.
CONCLUSION
Jass staging and the nature of the margin of invasion allow patients undergoing curative surgery for Dukes' B colorectal carcinoma to be separated into prognostic groups. A group of patients with Dukes' B tumours whose prognosis is inseparable from those with Dukes' C tumours can be identified, the nature of the margin of invasion being used to classify a larger number of patients.
To assess whether Jass staging enhances prognostic prediction in Dukes' B colorectal carcinoma.
DESIGN
A historical cohort observational study.
SETTING
A university tertiary care centre, Switzerland.
SUBJECTS
108 consecutive patients.
INTERVENTIONS
Curative resection of Dukes' B colorectal carcinoma between January 1985 and December 1988, Patients with familial adenomatous polyposis; hereditary non-polyposis colorectal cancer; Crohns' disease; ulcerative colitis and synchronous and recurrent tumours were excluded. A comparable group of 155 consecutive patients with Dukes' C carcinoma were included for reference purposes.
MAIN OUTCOME MEASURES
Disease free and overall survival for Dukes' B and overall survival for Dukes' C tumours.
RESULTS
Dukes' B tumours in Jass group III or with an infiltrated margin had a significantly worse disease-free survival (p = 0.001 and 0.0001, respectively) and those with infiltrated margins had a significantly worse overall survival (p = 0.002). Overall survival among those with Dukes' B Jass III and Dukes' B with infiltrated margins was no better than overall survival among all patients with Dukes' C tumours.
CONCLUSION
Jass staging and the nature of the margin of invasion allow patients undergoing curative surgery for Dukes' B colorectal carcinoma to be separated into prognostic groups. A group of patients with Dukes' B tumours whose prognosis is inseparable from those with Dukes' C tumours can be identified, the nature of the margin of invasion being used to classify a larger number of patients.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1080/110241599750006514
- PMID 10433145
- Persistent URL
- https://sonar.ch/global/documents/277797
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