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Hepatic nonoxidative disposal of an oral glucose meal in patients with liver cirrhosis.
Journal article

Hepatic nonoxidative disposal of an oral glucose meal in patients with liver cirrhosis.

  • 1999-10-27
Published in:
  • Metabolism: clinical and experimental. - 1999
Adult
Carbon Isotopes
Eating
Female
Galactose
Glucose
Glucose Intolerance
Humans
Hyperglycemia
Intestinal Absorption
Liver
Liver Cirrhosis
Liver Glycogen
Male
Middle Aged
Postprandial Period
Prothrombin Time
Reference Values
Uridine Diphosphate Glucose
English Seven patients with liver cirrhosis and five healthy subjects were studied over 4 hours after ingestion of a glucose meal to determine whether alterations of hepatic nonoxidative glucose disposal participate in the pathogenesis of impaired glucose tolerance. Hepatic uridyl-diphosphoglucose (UDPG) turnover was calculated from the isotopic enrichment of urinary acetaminophen glucuronide during continuous infusion of 13C-galactose and used as an index of hepatic glycogen synthesis. Patients with cirrhosis had postprandial hyperglycemia and decreased glucose clearance, but hepatic UDPG turnover was not altered (1.84 +/- 0.29 mg/kg fat-free mass min v 1.76 +/- 0.15 in controls, nonsignificant). It is concluded that hepatic postprandial glycogen synthesis is unaltered in patients with advanced cirrhosis, demonstrating important hepatic functional reserve.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/277803
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