Hepatic nonoxidative disposal of an oral glucose meal in patients with liver cirrhosis.

Schneiter P; Gillet M; Chioléro R; Jéquier E; Tappy L

doi:10.1016/s0026-0495(99)90265-2

Back

Journal article

Hepatic nonoxidative disposal of an oral glucose meal in patients with liver cirrhosis.

Schneiter P Institut de physiologie, Université de Lausanne, Switzerland.
Gillet M
Chioléro R
Jéquier E
Tappy L

1999-10-27

Published in:

Metabolism: clinical and experimental. - 1999

English Seven patients with liver cirrhosis and five healthy subjects were studied over 4 hours after ingestion of a glucose meal to determine whether alterations of hepatic nonoxidative glucose disposal participate in the pathogenesis of impaired glucose tolerance. Hepatic uridyl-diphosphoglucose (UDPG) turnover was calculated from the isotopic enrichment of urinary acetaminophen glucuronide during continuous infusion of 13C-galactose and used as an index of hepatic glycogen synthesis. Patients with cirrhosis had postprandial hyperglycemia and decreased glucose clearance, but hepatic UDPG turnover was not altered (1.84 +/- 0.29 mg/kg fat-free mass min v 1.76 +/- 0.15 in controls, nonsignificant). It is concluded that hepatic postprandial glycogen synthesis is unaltered in patients with advanced cirrhosis, demonstrating important hepatic functional reserve.

Language