Journal article
Antibacterial phloroglucinols and flavonoids from Hypericum brasiliense.
- Rocha L Institut de Pharmacognosie et Phytochimie, Université de Lausanne, Lausanne-Dorigny, Switzerland.
- Marston A
- Potterat O
- Kaplan MA
- Stoeckli-Evans H
- Hostettmann K
- 1995-11-01
Published in:
- Phytochemistry. - 1995
Anti-Bacterial Agents
Bacillus subtilis
Flavonoids
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Molecular Structure
Phloroglucinol
Plant Extracts
Plants, Medicinal
English
Three known phloroglucinols (japonicine A, uliginosin A and isouliginosin B) and a new phloroglucinol (hyperbrasiol A) have been isolated from a petrol extract of the leaves and flowers of Hypericum brasiliense. Their structures were established by spectroscopic methods (UV, DCI-MS, 1H and 13CNMR, including SINEPT, HMBC, HSQC, DQFCOSY experiments). The substitution pattern of hyperbrasilol A was confirmed by X-ray crystallography. All four phloroglucinols were antibacterial against Bacillus subtilis in a TLC bioautographic assay. The flavonoids, kaempferol, luteolin, quercetin, quercitrin, isoquercitrin, hyperoside and guaijaverin, were isolated from a methanol extract of the same organs.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/0031-9422(95)00507-4
- PMID 8534402
- Persistent URL
- https://sonar.ch/global/documents/277833
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