Journal article
Antifungal isopimaranes from Hypoestes serpens.
- Rasoamiaranjanahary L Institut de Pharmacognosie et Phytochimie, Université de Lausanne, CH-1015 Lausanne, Switzerland.
- Guilet D
- Marston A
- Randimbivololona F
- Hostettmann K
- 2003-08-29
Published in:
- Phytochemistry. - 2003
Acanthaceae
Antifungal Agents
Candida albicans
Cholinesterase Inhibitors
Cladosporium
Diterpenes
Magnetic Resonance Spectroscopy
Plant Leaves
Spectrometry, Mass, Electrospray Ionization
English
Five isopimarane diterpenes (7beta-hydroxyisopimara-8,15-dien-14-one, 14alpha-hydroxyisopimara-7,15-dien-1-one, 1beta,14alpha-dihydroxyisopimara-7,15-diene, 7beta-hydroxyisopimara-8(14),15-dien-1-one and 7beta-acetoxyisopimara-8(14),15-dien-1-one) have been isolated from the leaves of Hypoestes serpens (Acanthaceae). All compounds exhibited antifungal activity against both the plant pathogenic fungus Cladosporium cucumerinum and the yeast Candida albicans; two of them also displayed an acetylcholinesterase inhibition. The structures of the compounds were determined by means of spectrometric methods, including 1D and 2D NMR experiments and MS analysis.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/s0031-9422(03)00154-7
- PMID 12943772
- Persistent URL
- https://sonar.ch/global/documents/277919
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