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Effect of thyroid hormones on Lp(a) and lipid metabolism.
Journal article

Effect of thyroid hormones on Lp(a) and lipid metabolism.

  • Engler H Institute of Clinical Chemistry and Hematology, Kantonsspital, St. Gallen, Switzerland.
  • Riesen WF
  • 1998-11-06
Published in:
  • Clinical chemistry and laboratory medicine. - 1998
Adult
Aged
Case-Control Studies
Cross-Sectional Studies
Female
Humans
Lipid Metabolism
Lipoprotein(a)
Male
Middle Aged
Phenotype
Thyroid Gland
Thyroid Hormones
English The effect of thyroid hormones on lipoprotein(a) plasma concentrations and the other parameters of lipoprotein metabolism was studied in 158 patients with thyroid dysfunction and in 37 euthyroid controls (cross-sectional study). Multiple regression analysis revealed that 65.5% of the variability in lipoprotein(a) levels were predicted by changes in lipoprotein(a) phenotypes (60.5%), thyrotropin (3.5%), and age (0.8%). The lipid parameters, however, showed no significant effect on lipoprotein(a). A subgroup analysis on samples from patients with large lipoprotein(a) isoforms showed that 28% of the variability in lipoprotein(a) concentrations could be explained by changes in thyroid function (19.1%), age (6.5%) and triglycerides (3.5%). Much stronger correlations were found between thyrotropin and total cholesterol, low density lipoprotein cholesterol or apolipoprotein B respectively (R2=0.951 for low density lipoprotein cholesterol, R2=0.801 for apolipoprotein B). Our data suggest that thyroid hormone is a significant modulator of lipoprotein(a) metabolism. However, different mechanisms are responsible for the change in lipoprotein(a) levels and for the decrease in total- and low density lipoprotein cholesterol levels.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/278230
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