Journal article
Dicentric translocation (9;12) presenting as refractory Philadelphia chromosome-positive acute B-cell lymphoblastic leukemia.
- Bargetzi MJ Center of Oncology/Hematology and Transfusionmedicine, Kantonsspital Aarau, Switzerland.
- Mühlematter D
- Tichelli A
- Jotterand M
- Wernli M
- 1999-08-25
Published in:
- Cancer genetics and cytogenetics. - 1999
Aged
Burkitt Lymphoma
Chromosome Banding
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 9
Female
Humans
Karyotyping
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Recurrence
Translocation, Genetic
English
A 66-year-old Caucasian woman presented with a Philadelphia chromosome positive common B-cell acute lymphoblastic leukemia and a dic(9;12) involving the der(9)t(9;22), a rearrangement so far not observed in acute lymphoblastic leukemia. The patient was treated for the acute lymphoblastic leukemia, but showed refractory disease and died 6 months after initial diagnosis. This case suggests that, in the combination of t(9;22) and dic(9;12), the known poor prognostic feature of t(9;22) in acute lymphoblastic leukemia may outweigh the favorable outcome reported in patients with dic(9;12).
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/s0165-4608(98)00284-2
- PMID 10459354
- Persistent URL
- https://sonar.ch/global/documents/278363
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