Higher macrophage superoxide anion production in coronary artery disease (CAD) patients with Type D personality.
- Zuccarella-Hackl C Biological and Health Psychology, University of Bern, Bern, Switzerland; Department of Clinical Research, University of Bern, Bern, Switzerland.
- von Känel R Department of Clinical Research, University of Bern, Bern, Switzerland; Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland; Department of Psychosomatic Medicine, Clinic Barmelweid, Barmelweid, Switzerland.
- Thomas L Biological and Health Psychology, University of Bern, Bern, Switzerland; Biological Work and Health Psychology, University of Konstanz, Konstanz, Germany.
- Kuebler P Biological and Health Psychology, University of Bern, Bern, Switzerland.
- Schmid JP Cardiology Clinic, Tiefenauspital, Bern University Hospital, Bern, Switzerland.
- Mattle HP Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
- Mono ML Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
- Rieben R Department of Clinical Research, University of Bern, Bern, Switzerland.
- Wiest R Institute of Diagnostic and Interventional Neuroradiology, Bern University Hospital, and University of Bern, Bern, Switzerland.
- Wirtz PH Biological and Health Psychology, University of Bern, Bern, Switzerland; Biological Work and Health Psychology, University of Konstanz, Konstanz, Germany. Electronic address: petra.wirtz@uni-konstanz.de.
- 2016-03-21
Published in:
- Psychoneuroendocrinology. - 2016
CAD
Human macrophages
NADPH oxidase
Superoxide anions
Type D personality
Aged
Cardiovascular Diseases
Case-Control Studies
Coronary Artery Disease
Depression
Humans
Macrophages
Male
Middle Aged
Risk Factors
Superoxides
Type D Personality
English
BACKGROUND
Type D personality (Type D) is an independent psychosocial risk factor for poor cardiac prognosis and increased mortality in patients with cardiovascular disease (CVD), but the involved mechanisms are poorly understood. Macrophages play a pivotal role in atherosclerosis, the process underlying coronary artery disease (CAD). We investigated macrophage superoxide anion production in production in CAD patients with and without Type D.
METHODS AND RESULTS
We studied 20 male CAD patients with Type D (M:66.7±9.9years) and 20 age-matched male CAD patients without Type D (M:67.7±8.5years). Type D was measured using the DS14 questionnaire with the two subscales 'negative affectivity' and 'social inhibition'. We assessed macrophage superoxide anion production using the WST-1 assay. All analyses were controlled for potential confounders. CAD patients with Type D showed higher superoxide anion production compared to CAD patients without Type D (F(1,38)=15.57, p<0.001). Complementary analyses using the Type D subscales 'negative affectivity' and 'social inhibition', and their interaction as continuous measures, showed that both Type D subscales (negative affectivity: (ß=0.48, p=0.002, R(2)=0.227); social inhibition: (ß=0.46, p=0.003, R(2)=0.208)) and their interaction (ß=0.36, p=0.022, R(2)=0.130) were associated with higher WST-1 reduction scores. Results remained significant when controlling for classical CVD risk factors (i.e. body mass index, mean arterial blood pressure), atherosclerosis severity (i.e. intima media thickness, presence of carotid plaques), and psychological factors (depressive symptom severity, chronic stress).
CONCLUSIONS
Our results indicate higher macrophage superoxide anion production in CAD patients with Type D compared to those without Type D. This may suggest a mechanism contributing to increased morbidity and mortality in CAD patients with Type D.
Type D personality (Type D) is an independent psychosocial risk factor for poor cardiac prognosis and increased mortality in patients with cardiovascular disease (CVD), but the involved mechanisms are poorly understood. Macrophages play a pivotal role in atherosclerosis, the process underlying coronary artery disease (CAD). We investigated macrophage superoxide anion production in production in CAD patients with and without Type D.
METHODS AND RESULTS
We studied 20 male CAD patients with Type D (M:66.7±9.9years) and 20 age-matched male CAD patients without Type D (M:67.7±8.5years). Type D was measured using the DS14 questionnaire with the two subscales 'negative affectivity' and 'social inhibition'. We assessed macrophage superoxide anion production using the WST-1 assay. All analyses were controlled for potential confounders. CAD patients with Type D showed higher superoxide anion production compared to CAD patients without Type D (F(1,38)=15.57, p<0.001). Complementary analyses using the Type D subscales 'negative affectivity' and 'social inhibition', and their interaction as continuous measures, showed that both Type D subscales (negative affectivity: (ß=0.48, p=0.002, R(2)=0.227); social inhibition: (ß=0.46, p=0.003, R(2)=0.208)) and their interaction (ß=0.36, p=0.022, R(2)=0.130) were associated with higher WST-1 reduction scores. Results remained significant when controlling for classical CVD risk factors (i.e. body mass index, mean arterial blood pressure), atherosclerosis severity (i.e. intima media thickness, presence of carotid plaques), and psychological factors (depressive symptom severity, chronic stress).
CONCLUSIONS
Our results indicate higher macrophage superoxide anion production in CAD patients with Type D compared to those without Type D. This may suggest a mechanism contributing to increased morbidity and mortality in CAD patients with Type D.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1016/j.psyneuen.2016.02.031
- PMID 26994482
- Persistent URL
- https://sonar.ch/global/documents/278450
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