Journal article
Impact of local endothelial shear stress on neointima and plaque following stent implantation in patients with ST-elevation myocardial infarction: A subgroup-analysis of the COMFORTABLE AMI-IBIS 4 trial.
- Bourantas CV Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, The Netherlands; University College of London, London, United Kingdom.
- Räber L Department of Interventional Cardiology, Bern University Hospital, Bern, Switzerland.
- Zaugg S Clinical Trials Unit, Bern University, Bern, Switzerland.
- Sakellarios A Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece.
- Taniwaki M Department of Interventional Cardiology, Bern University Hospital, Bern, Switzerland.
- Heg D Clinical Trials Unit, Bern University, Bern, Switzerland; Institute of Social and Preventive Medicine, Bern University, Bern, Switzerland.
- Moschovitis A Department of Interventional Cardiology, Bern University Hospital, Bern, Switzerland.
- Radu M The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
- Papafaklis MI Department of Cardiology, Medical School, University of Ioannina, Ioannina, Greece.
- Kalatzis F Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece.
- Naka KK Department of Cardiology, Medical School, University of Ioannina, Ioannina, Greece.
- Fotiadis DI Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece.
- Michalis LK Department of Cardiology, Medical School, University of Ioannina, Ioannina, Greece.
- Serruys PW Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, The Netherlands.
- Garcia Garcia HM Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, The Netherlands.
- Windecker S Department of Interventional Cardiology, Bern University Hospital, Bern, Switzerland. Electronic address: stephan.windecker@insel.ch.
- 2015-04-02
Published in:
- International journal of cardiology. - 2015
Endothelial shear stress
Neo-atherosclerosis
Neointimal formation
Aged
Blood Vessel Prosthesis Implantation
Coronary Angiography
Double-Blind Method
Drug-Eluting Stents
Electrocardiography
Endothelium, Vascular
Female
Humans
Male
Middle Aged
Myocardial Infarction
Neointima
Stents
Stress, Mechanical
English
BACKGROUND
Numerous studies have demonstrated an association between endothelial shear stress (ESS) and neointimal formation after stent implantation. However, the role of ESS on the composition of neointima and underlying plaque remains unclear.
METHODS
Patients recruited in the Comfortable AMI-IBIS 4 study implanted with bare metal stents (BMS) or biolimus eluting stents (BES) that had biplane coronary angiography at 13 month follow-up were included in the analysis. The intravascular ultrasound virtual-histology (IVUS-VH) and the angiographic data were used to reconstruct the luminal surface, and the stent in the stented segments. Blood flow simulation was performed in the stent surface, which was assumed to represent the luminal surface at baseline, to assess the association between ESS and neointima thickness. The predominant ESS was estimated in 3-mm segments and was correlated with the amount of neointima, neointimal tissue composition, and with the changes in the underlying plaque burden and composition.
RESULTS
Forty three patients (18 implanted with BMS and 25 with BES) were studied. In both stent groups negative correlations were noted between ESS and neointima thickness in BMS (P < 0.001) and BES (P = 0.002). In BMS there was a negative correlation between predominant ESS and the percentage of the neointimal necrotic core component (P = 0.015). In BES group, the limited neointima formation did not allow evaluation of the effect of ESS on its tissue characteristics. ESS did not affect vessel wall remodeling and the plaque burden and composition behind BMS (P > 0.10) and BES (P > 0.45).
CONCLUSIONS
ESS determines neointimal formation in both BMS and BES and affects the composition of the neointima in BMS. Conversely, ESS does not impact the plaque behind struts irrespective of stent type throughout 13 months of follow-up.
Numerous studies have demonstrated an association between endothelial shear stress (ESS) and neointimal formation after stent implantation. However, the role of ESS on the composition of neointima and underlying plaque remains unclear.
METHODS
Patients recruited in the Comfortable AMI-IBIS 4 study implanted with bare metal stents (BMS) or biolimus eluting stents (BES) that had biplane coronary angiography at 13 month follow-up were included in the analysis. The intravascular ultrasound virtual-histology (IVUS-VH) and the angiographic data were used to reconstruct the luminal surface, and the stent in the stented segments. Blood flow simulation was performed in the stent surface, which was assumed to represent the luminal surface at baseline, to assess the association between ESS and neointima thickness. The predominant ESS was estimated in 3-mm segments and was correlated with the amount of neointima, neointimal tissue composition, and with the changes in the underlying plaque burden and composition.
RESULTS
Forty three patients (18 implanted with BMS and 25 with BES) were studied. In both stent groups negative correlations were noted between ESS and neointima thickness in BMS (P < 0.001) and BES (P = 0.002). In BMS there was a negative correlation between predominant ESS and the percentage of the neointimal necrotic core component (P = 0.015). In BES group, the limited neointima formation did not allow evaluation of the effect of ESS on its tissue characteristics. ESS did not affect vessel wall remodeling and the plaque burden and composition behind BMS (P > 0.10) and BES (P > 0.45).
CONCLUSIONS
ESS determines neointimal formation in both BMS and BES and affects the composition of the neointima in BMS. Conversely, ESS does not impact the plaque behind struts irrespective of stent type throughout 13 months of follow-up.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.ijcard.2015.03.160
- PMID 25828109
- Persistent URL
- https://sonar.ch/global/documents/278459
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