Journal article
The impact of different doses of indocyanine green on the sentinel lymph-node mapping in early stage endometrial cancer.
- Papadia A Department of Obstetrics and Gynecology, University Hospital of Bern, University of Bern, Effingerstrasse 102, 3010, Bern, Switzerland. andrea.papadia@insel.ch.
- Buda A Unit of Gynecologic Oncology Surgery, Department of Obstetrics and Gynecology, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
- Gasparri ML Department of Obstetrics and Gynecology, University Hospital of Bern, University of Bern, Effingerstrasse 102, 3010, Bern, Switzerland.
- Di Martino G Unit of Gynecologic Oncology Surgery, Department of Obstetrics and Gynecology, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
- Bussi B Unit of Gynecologic Oncology Surgery, Department of Obstetrics and Gynecology, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
- Verri D Unit of Gynecologic Oncology Surgery, Department of Obstetrics and Gynecology, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
- Mueller MD Department of Obstetrics and Gynecology, University Hospital of Bern, University of Bern, Effingerstrasse 102, 3010, Bern, Switzerland.
- 2018-07-26
Published in:
- Journal of cancer research and clinical oncology. - 2018
Dose
Endometrial cancer
Indocyanine green
Laparoscopy
Sentinel lymph-node mapping
Adult
Aged
Aged, 80 and over
Endometrial Neoplasms
Female
Humans
Indocyanine Green
Laparoscopy
Middle Aged
Multivariate Analysis
Neoplasm Staging
Prognosis
Retrospective Studies
Sentinel Lymph Node
Sentinel Lymph Node Biopsy
English
INTRODUCTION
Aim of the study is to evaluate the impact of different doses of indocyanine green (ICG) on the sentinel lymph-node (SLN) mapping in endometrial cancer (EC).
MATERIALS AND METHODS
A retrospective analysis of EC patients undergoing a laparoscopic SLN mapping at two institutions was performed. Two different injection protocols were used (protocol # 1: 5 mg/ml and a volume of 8 ml; protocol # 2: 1.25 mg/ml and a volume of 4 ml). In every case, the injection was intracervical. The laparoscopic equipment adopted was the same among both institutions. Overall and bilateral detection rates (DR) and median number of retrieved SLNs were calculated. At uni- and multivariate analysis factors (including ICG dose) associated with DR and number of detected SLNs were investigated.
RESULTS
Overall, 168 patients were included. The overall and bilateral DR were 96.3 and 84.5%. Median number of removed SLNs was 3 (0-18). In 56% of the patients, a median number of 6 (1-93) non-SLNs (NSLNs) were removed. Seventeen (10.1%) patients had metastatic SLNs. At multivariate analysis, no factors were associated with bilateral DR. ICG dose was the only factor associated with number of removed SLNs at multivariate analysis.
CONCLUSION
A larger dose of ICG is associated with a higher number of retrieved SLNs but not with an increased bilateral DR.
Aim of the study is to evaluate the impact of different doses of indocyanine green (ICG) on the sentinel lymph-node (SLN) mapping in endometrial cancer (EC).
MATERIALS AND METHODS
A retrospective analysis of EC patients undergoing a laparoscopic SLN mapping at two institutions was performed. Two different injection protocols were used (protocol # 1: 5 mg/ml and a volume of 8 ml; protocol # 2: 1.25 mg/ml and a volume of 4 ml). In every case, the injection was intracervical. The laparoscopic equipment adopted was the same among both institutions. Overall and bilateral detection rates (DR) and median number of retrieved SLNs were calculated. At uni- and multivariate analysis factors (including ICG dose) associated with DR and number of detected SLNs were investigated.
RESULTS
Overall, 168 patients were included. The overall and bilateral DR were 96.3 and 84.5%. Median number of removed SLNs was 3 (0-18). In 56% of the patients, a median number of 6 (1-93) non-SLNs (NSLNs) were removed. Seventeen (10.1%) patients had metastatic SLNs. At multivariate analysis, no factors were associated with bilateral DR. ICG dose was the only factor associated with number of removed SLNs at multivariate analysis.
CONCLUSION
A larger dose of ICG is associated with a higher number of retrieved SLNs but not with an increased bilateral DR.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1007/s00432-018-2716-3
- PMID 30043278
- Persistent URL
- https://sonar.ch/global/documents/278760
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