Journal article
Inferior frontal gyrus gray matter volume is associated with aggressive behavior in schizophrenia spectrum disorders.
- Schoretsanitis G University of Bern, University Hospital of Psychiatry, Bern, Switzerland; Department of Psychiatry, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, USA; Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY, USA. Electronic address: george.schor@gmail.com.
- Stegmayer K University of Bern, University Hospital of Psychiatry, Bern, Switzerland.
- Razavi N University of Bern, University Hospital of Psychiatry, Bern, Switzerland.
- Federspiel A University of Bern, University Hospital of Psychiatry, Bern, Switzerland.
- Müller TJ University of Bern, University Hospital of Psychiatry, Bern, Switzerland; Privatklinik Meiringen, Meiringen, Switzerland.
- Horn H Institute of Psychiatry and Psychotherapy Bern, Switzerland; University of Bern, University Hospital of Psychiatry, Bern, Switzerland.
- Wiest R Institute of Neuroradiology, Inselspital, Bern, Switzerland.
- Strik W University of Bern, University Hospital of Psychiatry, Bern, Switzerland.
- Walther S University of Bern, University Hospital of Psychiatry, Bern, Switzerland.
- 2019-06-30
Published in:
- Psychiatry research. Neuroimaging. - 2019
Aggression
Gray matter volume
Schizophrenia
State markers
Violence
Adult
Aged
Aggression
Female
Gray Matter
Humans
Male
Middle Aged
Organ Size
Prefrontal Cortex
Schizophrenia
Schizophrenic Psychology
Verbal Behavior
Young Adult
English
We aimed to assess potential gray matter (GM) alterations for aggressive patterns of behavior in a sample of in- and outpatients with schizophrenia spectrum disorders. Eighty-four patients previously participating in brain volumetric studies were included. Aggression was assessed using the Modified Overt Aggression Scales (MOAS) based upon review of clinical records of the hospital register. Multiple regression analyses for total MOAS and each MOAS subscale separately were conducted correcting for age, sex, history of addiction, chlorpromazine equivalents, illness duration, and total intracranial volume. Significant effects were reported in two cases; the total MOAS scores and MOAS verbal aggression scores were associated with GM volume in left inferior frontal gyrus. From the demographic/clinical characteristics, only the number of episodes correlated with the subscales and the total MOAS scores. Our results highlight the role of GM volume in left inferior frontal gyri in patients with history of aggression. This evidence ties in well with previous data reporting involvement of these regions in response control and semantic networks.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.pscychresns.2019.06.003
- PMID 31254799
- Persistent URL
- https://sonar.ch/global/documents/279406
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