Bioinformatics and HIV latency.
- Ciuffi A Institute of Microbiology, University Hospital of Lausanne (CHUV), University of Lausanne, Bugnon 48, 1011, Lausanne, Switzerland, angela.ciuffi@chuv.ch.
- Mohammadi P
- Golumbeanu M
- di Iulio J
- Telenti A
- 2015-01-15
Published in:
- Current HIV/AIDS reports. - 2015
English
Despite effective treatment, HIV is not completely eliminated from the infected organism because of the existence of viral reservoirs. A major reservoir consists of infected resting CD4+ T cells, mostly of memory type, that persist over time due to the stable proviral insertion and a long cellular lifespan. Resting cells do not produce viral particles and are protected from viral-induced cytotoxicity or immune killing. However, these latently infected cells can be reactivated by stochastic events or by external stimuli. The present review focuses on novel genome-wide technologies applied to the study of integration, transcriptome, and proteome characteristics and their recent contribution to the understanding of HIV latency.
- Language
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- English
- Open access status
- hybrid
- Identifiers
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- DOI 10.1007/s11904-014-0240-x
- PMID 25586146
- Persistent URL
- https://sonar.ch/global/documents/281337
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