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The contrasting phylodynamics of human influenza B viruses.
Journal article

The contrasting phylodynamics of human influenza B viruses.

  • Vijaykrishna D Duke-NUS Graduate Medical School, Singapore, Singapore.
  • Holmes EC Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia.
  • Joseph U Duke-NUS Graduate Medical School, Singapore, Singapore.
  • Fourment M Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia.
  • Su YC Duke-NUS Graduate Medical School, Singapore, Singapore.
  • Halpin R J Craig Venter Institute, Rockville, United States.
  • Lee RT Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore.
  • Deng YM World Health Organisation Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
  • Gunalan V Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore.
  • Lin X J Craig Venter Institute, Rockville, United States.
  • Stockwell TB J Craig Venter Institute, Rockville, United States.
  • Fedorova NB J Craig Venter Institute, Rockville, United States.
  • Zhou B J Craig Venter Institute, Rockville, United States.
  • Spirason N World Health Organisation Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
  • Kühnert D Department of Environmental Systems Science, Eidgenössische Technische Hochschule Zürich, Zürich, Switzerland.
  • Bošková V Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule Zürich, Zurich, Switzerland.
  • Stadler T Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule Zürich, Zurich, Switzerland.
  • Costa AM Royal Children's Hospital, Parkville, Australia.
  • Dwyer DE Centre for Infectious Diseases and Microbiology Laboratory Services, Westmead Hospital and University of Sydney, Westmead, Australia.
  • Huang QS Institute of Environmental Science and Research, National Centre for Biosecurity and Infectious Disease, Upper Hutt, New Zealand.
  • Jennings LC Microbiology Department, Canterbury Health Laboratories, Christchurch, New Zealand.
  • Rawlinson W Virology Division, SEALS Microbiology, Prince of Wales Hospital, Sydney, Australia.
  • Sullivan SG World Health Organisation Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
  • Hurt AC World Health Organisation Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
  • Maurer-Stroh S Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore.
  • Wentworth DE J Craig Venter Institute, Rockville, United States.
  • Smith GJ Duke-NUS Graduate Medical School, Singapore, Singapore.
  • Barr IG World Health Organisation Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
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  • 2015-01-17
Published in:
  • eLife. - 2015
antigenic drift
epidemiology
evolution
evolutionary biology
genomics
human
infectious disease
influenza virus
microbiology
viruses
Age Distribution
Animals
Antigens, Viral
Asparagine
Dogs
Evolution, Molecular
Genetic Variation
Genome, Viral
Glycosylation
Hemagglutinin Glycoproteins, Influenza Virus
Humans
Influenza A virus
Influenza B virus
Influenza, Human
Madin Darby Canine Kidney Cells
Models, Molecular
New Zealand
Phylogeny
Reassortant Viruses
Selection, Genetic
Time Factors
Victoria
English A complex interplay of viral, host, and ecological factors shapes the spatio-temporal incidence and evolution of human influenza viruses. Although considerable attention has been paid to influenza A viruses, a lack of equivalent data means that an integrated evolutionary and epidemiological framework has until now not been available for influenza B viruses, despite their significant disease burden. Through the analysis of over 900 full genomes from an epidemiological collection of more than 26,000 strains from Australia and New Zealand, we reveal fundamental differences in the phylodynamics of the two co-circulating lineages of influenza B virus (Victoria and Yamagata), showing that their individual dynamics are determined by a complex relationship between virus transmission, age of infection, and receptor binding preference. In sum, this work identifies new factors that are important determinants of influenza B evolution and epidemiology.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/286487
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