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Insulin-like growth factors.
Journal article

Insulin-like growth factors.

  • Schmid C Department of Medicine, University Hospital, Zurich, Switzerland.
  • 1995-05-01
Published in:
  • Cell biology international. - 1995
Animals
Bone Development
Carrier Proteins
Cartilage
Cell Differentiation
Cell Division
Cell Survival
Collagen
Dwarfism
Homeostasis
Humans
Insulin-Like Growth Factor II
Osteoblasts
Osteoporosis
Proteoglycans
Receptor, IGF Type 1
Receptor, IGF Type 2
Wound Healing
English The insulin-like growth factors I and II are single chain polypeptides homologous to proinsulin. IGF I and IGF II contribute to cell regulation and stimulate protein synthesis via signaling through type 1 receptors which are homologous to insulin receptors and activate phosphorylation cascades. IGFs enhance the proliferation of chondocytes and the proliferation of their collagen and proteoglycan matrix; IGFs stimulate longitudinal (endochondral) bone growth. Throughout life, IGFs are constitutively expressed ubiquitous factors which help to maintain the survival of differentiated cells, Increased expression is found during growth and tissue repair, Six specific binding proteins, IGFBP 1-6, allow additional tissue compartment specific control of IGF activity; IGFBP production favours storage and IGFBP cleavage leads to activation.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/286637
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