Lysolecithin actions on vascular smooth muscle cells.

Locher R; Weisser B; Mengden T; Brunner C; Vetter W

doi:10.1016/0006-291x(92)91622-w

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Journal article

Lysolecithin actions on vascular smooth muscle cells.

Locher R Department of Internal Medicine, University Hospital, Zürich, Switzerland.
Weisser B
Mengden T
Brunner C
Vetter W

1992-02-28

Published in:

Biochemical and biophysical research communications. - 1992

Dose-Response Relationship, Drug

Platelet-Derived Growth Factor

English Oxidation of low density lipoprotein increases its atherogenic potential. During oxidation there is an extensive conversion of lecithin to lysolecithin. In rat aortic smooth muscle cells, 2-25 micrograms/ml lysolecithin elevated cytosolic calcium concentration up to 560%. Lysolecithin (10-20 micrograms/ml) increased [3H]thymidine incorporation from 15 cpm/mg cell protein (controls) up to 189 cpm/mg cell protein. Lysolecithin (10 micrograms/ml) potentiated the PDGF-induced (50 ng/ml) [3H]thymidine incorporation up to 6.3 times. The results indicate that lysolecithin could induce mechanisms, by which oxidized low density lipoproteins could promote cell growth and thus contribute to atherosclerosis.

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