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Extracellular vesicles: Future diagnostic and therapeutic tools for liver disease and regeneration.

  • Balaphas A Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland.
  • Meyer J Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland.
  • Sadoul R Université Grenoble Alpes, Institut des Neurosciences, Grenoble, France.
  • Morel P Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland.
  • Gonelle-Gispert C Surgical Research Unit, University Hospitals of Geneva, Geneva, Switzerland.
  • Bühler LH Division of Digestive Surgery, University Hospitals of Geneva, Geneva, Switzerland.
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  • 2019-07-10
Published in:
  • Liver international : official journal of the International Association for the Study of the Liver. - 2019
exosome
extracellular vesicle
liver injury
liver regeneration
microparticle
microvesicle
Animals
Biomarkers
Cell Communication
Disease Models, Animal
Extracellular Vesicles
Humans
Liver Diseases
Regeneration
English Extracellular vesicles are membrane fragments that can be produced by all cell types. Interactions between extracellular vesicles and various liver cells constitute an emerging field in hepatology and recent evidences have established a role for extracellular vesicles in various liver diseases and physiological processes. Extracellular vesicles originating from liver cells are implicated in intercellular communication and fluctuations of specific circulating extracellular vesicles could constitute new diagnostic tools. In contrast, extracellular vesicles derived from progenitor cells interact with hepatocytes or non-parenchymal cells, thereby protecting the liver from various injuries and promoting liver regeneration. Our review focuses on recent developments investigating the role of various types of extracellular vesicles in acute and chronic liver diseases as well as their potential use as biomarkers and therapeutic tools.
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  • English
Open access status
bronze
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https://sonar.ch/global/documents/287677
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