Cell Adhesion by Integrins.
- Bachmann M Department of Cell Physiology and Metabolism, University of Geneva, Centre Médical Universitaire , Geneva , Switzerland ; and Faculty of Medicine and Health Technology, Tampere University, and Fimlab Laboratories , Tampere , Finland.
- Kukkurainen S Department of Cell Physiology and Metabolism, University of Geneva, Centre Médical Universitaire , Geneva , Switzerland ; and Faculty of Medicine and Health Technology, Tampere University, and Fimlab Laboratories , Tampere , Finland.
- Hytönen VP Department of Cell Physiology and Metabolism, University of Geneva, Centre Médical Universitaire , Geneva , Switzerland ; and Faculty of Medicine and Health Technology, Tampere University, and Fimlab Laboratories , Tampere , Finland.
- Wehrle-Haller B Department of Cell Physiology and Metabolism, University of Geneva, Centre Médical Universitaire , Geneva , Switzerland ; and Faculty of Medicine and Health Technology, Tampere University, and Fimlab Laboratories , Tampere , Finland.
- 2019-07-18
Published in:
- Physiological reviews. - 2019
cell adhesion
fibronectin
integrin
mechanosensing
talin
Adaptor Proteins, Signal Transducing
Animals
Cell Adhesion
Cell Membrane
Cell Proliferation
Extracellular Matrix
Humans
Integrins
Intracellular Signaling Peptides and Proteins
Mechanotransduction, Cellular
Models, Molecular
Phosphoproteins
Protein Conformation
Structure-Activity Relationship
Transcription Factors
English
Integrins are heterodimeric cell surface receptors ensuring the mechanical connection between cells and the extracellular matrix. In addition to the anchorage of cells to the extracellular matrix, these receptors have critical functions in intracellular signaling, but are also taking center stage in many physiological and pathological conditions. In this review, we provide some historical, structural, and physiological notes so that the diverse functions of these receptors can be appreciated and put into the context of the emerging field of mechanobiology. We propose that the exciting journey of the exploration of these receptors will continue for at least another new generation of researchers.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1152/physrev.00036.2018
- PMID 31313981
- Persistent URL
- https://sonar.ch/global/documents/287852
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