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Botulinum toxin A in non-dystonic tremors.
Journal article

Botulinum toxin A in non-dystonic tremors.

  • 1996-01-01
Published in:
  • European neurology. - 1996
Adult
Aged
Botulinum Toxins
Electromyography
Female
Humans
Male
Middle Aged
Placebos
Severity of Illness Index
Single-Blind Method
Treatment Outcome
Tremor
English The present pilot study evaluated the effect of botulinum toxin A on primarily non-dystonic tremors using accelerometry in a single-blind, placebo-controlled design. Resting, postural, intention, or head tremor were assessed before and approximately 1 month after intramuscular saline and botulinum toxin A (25-50 U) respectively. Half of the patients showed > or = 30% placebo effect. Tremor in 10 of 17 patients (60%) studied improved further after botulinum toxin A (range 30-95%), exceeding the placebo effect by > or = 30%. Nine patients demonstrated clinically significant focal weakness in the extensor muscles after botulinum toxin A which interfered with fine movements. Patients were subdivided into PD-like and ET-like tremor(s). Both groups experienced large placebo effects for resting tremor, with little or no further improvement after botulinum toxin A. The improvement in postural tremor after botulinum toxin A, of 40% in the PD-like and 57% in the ET-like groups, however, was approximately twice that of placebo. In conclusion, botulinum toxin A exerts a modest tremorlytic effect, however the dose, and its distribution over the sites injected, need to be optimised to minimise focal weakness.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/290085
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