Journal article
Daptomycin for highly resistant Enterococcus faecium infection.
- Rosin C Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Basel, Switzerland. rosinc@uhbs.ch
- Bernsmeier C
- Entenza JM
- Moreillon P
- Frei R
- Weisser M
- Flückiger U
- 2012-06-28
Published in:
- Swiss medical weekly. - 2012
Aged
Aged, 80 and over
Anti-Bacterial Agents
Bacteremia
Daptomycin
Drug Resistance, Bacterial
Drug Therapy, Combination
Enterococcus faecium
Female
Humans
Male
Microbial Sensitivity Tests
Middle Aged
English
We report a case series of 11 patients with severe E. faecium infections treated with daptomycin. All strains were resistant to ampicillin (MIC >8 mg/l), but susceptible to vancomycin. Seven out of 11 strains were also highly resistant to gentamicin (MIC >500 mg/l). All patients were treated with multiple broad-spectrum antibiotics prior to isolation of E. faecium and had severe underlying diseases. Our experience suggests that salvage therapy with daptomycin might be a safe and efficacious treatment for E. faecium infections.
- Language
-
- English
- Open access status
- gold
- Identifiers
-
- DOI 10.4414/smw.2012.13603
- PMID 22736040
- Persistent URL
- https://sonar.ch/global/documents/291030
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