Eleven faces of coronavirus disease 2019.
- Dong X Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China.
- Cao YY Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
- Lu XX Department of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
- Zhang JJ Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China.
- Du H Department of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
- Yan YQ Department of Infectious Disease, No. 7 Hospital of Wuhan, Wuhan, China.
- Akdis CA Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
- Gao YD Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China.
- 2020-03-21
Published in:
- Allergy. - 2020
SARS-CoV-2
allergic diseases
case reports
clinical characteristics
coronavirus disease 2019
Adult
Aged
Antibodies, Viral
Antiviral Agents
Asymptomatic Diseases
Betacoronavirus
Child, Preschool
Coronavirus Infections
Female
Humans
Immunoglobulin G
Immunoglobulin M
Male
Middle Aged
Pandemics
Pneumonia, Viral
Reverse Transcriptase Polymerase Chain Reaction
Tomography, X-Ray Computed
Treatment Outcome
Young Adult
English
BACKGROUND AND AIMS
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has recently spread worldwide and been declared a pandemic. We aim to describe here the various clinical presentations of this disease by examining eleven cases.
METHODS
Electronic medical records of 11 patients with COVID-19 were collected, and demographics, clinical manifestations, outcomes, key laboratory results, and radiological images are discussed.
RESULTS
The clinical course of the eleven cases demonstrated the complexity of the COVID-19 profile with different clinical presentations. Clinical manifestations range from asymptomatic cases to patients with mild and severe symptoms, with or without pneumonia. Laboratory detection of the viral nucleic acid can yield false-negative results, and serological testing of virus-specific IgG and IgM antibodies should be used as an alternative for diagnosis. Patients with common allergic diseases did not develop distinct symptoms and severe courses. Cases with a pre-existing condition of chronic obstructive pulmonary disease or complicated with a secondary bacterial pneumonia were more severe.
CONCLUSION
All different clinical characteristics of COVID-19 should be taken into consideration to identify patients that need to be in strict quarantine for the efficient containment of the pandemic.
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has recently spread worldwide and been declared a pandemic. We aim to describe here the various clinical presentations of this disease by examining eleven cases.
METHODS
Electronic medical records of 11 patients with COVID-19 were collected, and demographics, clinical manifestations, outcomes, key laboratory results, and radiological images are discussed.
RESULTS
The clinical course of the eleven cases demonstrated the complexity of the COVID-19 profile with different clinical presentations. Clinical manifestations range from asymptomatic cases to patients with mild and severe symptoms, with or without pneumonia. Laboratory detection of the viral nucleic acid can yield false-negative results, and serological testing of virus-specific IgG and IgM antibodies should be used as an alternative for diagnosis. Patients with common allergic diseases did not develop distinct symptoms and severe courses. Cases with a pre-existing condition of chronic obstructive pulmonary disease or complicated with a secondary bacterial pneumonia were more severe.
CONCLUSION
All different clinical characteristics of COVID-19 should be taken into consideration to identify patients that need to be in strict quarantine for the efficient containment of the pandemic.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1111/all.14289
- PMID 32196678
- Persistent URL
- https://sonar.ch/global/documents/296315
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