Journal article
Effects of a simple home exercise program and vitamin D supplementation on health-related quality of life after a hip fracture: a randomized controlled trial.
- Renerts K Department of Geriatrics and Aging Research, University Hospital Zurich and University of Zurich, RAE B1, Rämistrasse 100, 8091, Zurich, Switzerland.
- Fischer K Department of Geriatrics and Aging Research, University Hospital Zurich and University of Zurich, RAE B1, Rämistrasse 100, 8091, Zurich, Switzerland.
- Dawson-Hughes B Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
- Orav EJ Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
- Freystaetter G Department of Geriatrics and Aging Research, University Hospital Zurich and University of Zurich, RAE B1, Rämistrasse 100, 8091, Zurich, Switzerland.
- Simmen HP Centre for Senior Trauma Care, University Hospital Zurich, Zurich, Switzerland.
- Pape HC Centre for Senior Trauma Care, University Hospital Zurich, Zurich, Switzerland.
- Egli A Department of Geriatrics and Aging Research, University Hospital Zurich and University of Zurich, RAE B1, Rämistrasse 100, 8091, Zurich, Switzerland.
- Theiler R Department of Geriatrics and Aging Research, University Hospital Zurich and University of Zurich, RAE B1, Rämistrasse 100, 8091, Zurich, Switzerland.
- Bischoff-Ferrari HA Department of Geriatrics and Aging Research, University Hospital Zurich and University of Zurich, RAE B1, Rämistrasse 100, 8091, Zurich, Switzerland. Heike.Bischoff@usz.ch.
- 2019-02-11
Published in:
- Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. - 2019
Elderly
Exercise
Hip fracture
Quality of life
RCT
Vitamin D
Aged
Aged, 80 and over
Dietary Supplements
Exercise Therapy
Female
Hip Fractures
Humans
Male
Quality of Life
Surveys and Questionnaires
Vitamin D
English
PURPOSE
To test the effects of vitamin D intervention and a simple home exercise program (HE) on health-related quality of life (HRQL) in the first 12 months after hip fracture.
METHODS
HRQL was reported in 173 acute hip fracture patients (mean age 84 years, 79% females, 77% community dwelling) who were enrolled in the 12-month 2 × 2 factorial Zurich Hip Fracture Trial. Pre-fracture HRQL was assessed at baseline (4.2 ± 2.2 days post-surgery) and then again at 6 and 12 months after hip fracture surgery by the EuroQol EQ-5D-3L index value (EQ-5D-3L questionnaire). The effects of vitamin D intervention (2000 vs. 800 IU vitamin D3) and exercise (HE vs. no HE) or of the combined interventions on HRQL were assessed using multivariable-adjusted repeated-measures linear mixed-effects regression models.
RESULTS
The EQ-5D-3L index value significantly worsened from 0.71 pre-fracture to 0.57 over 12 months, but the degree of worsening did not differ between individual or combined interventions. However, regarding only the late recovery between 6 and 12 months, the group receiving neither intervention (800 IU/day and no HE) experienced a significant further decline in the EQ-5D-3L index value (adjusted mean change = 0.08 [95% CI 0.009, 0.15], p = 0.03) while all other groups remained stable.
CONCLUSION
Hip fractures have a long-lasting negative effect on HRQL up to 12 months after hip fracture. However, HE and/or 2000 IU vitamin D per day may help prevent a further decline in HRQL after the first 6 months following the acute hip fracture event.
To test the effects of vitamin D intervention and a simple home exercise program (HE) on health-related quality of life (HRQL) in the first 12 months after hip fracture.
METHODS
HRQL was reported in 173 acute hip fracture patients (mean age 84 years, 79% females, 77% community dwelling) who were enrolled in the 12-month 2 × 2 factorial Zurich Hip Fracture Trial. Pre-fracture HRQL was assessed at baseline (4.2 ± 2.2 days post-surgery) and then again at 6 and 12 months after hip fracture surgery by the EuroQol EQ-5D-3L index value (EQ-5D-3L questionnaire). The effects of vitamin D intervention (2000 vs. 800 IU vitamin D3) and exercise (HE vs. no HE) or of the combined interventions on HRQL were assessed using multivariable-adjusted repeated-measures linear mixed-effects regression models.
RESULTS
The EQ-5D-3L index value significantly worsened from 0.71 pre-fracture to 0.57 over 12 months, but the degree of worsening did not differ between individual or combined interventions. However, regarding only the late recovery between 6 and 12 months, the group receiving neither intervention (800 IU/day and no HE) experienced a significant further decline in the EQ-5D-3L index value (adjusted mean change = 0.08 [95% CI 0.009, 0.15], p = 0.03) while all other groups remained stable.
CONCLUSION
Hip fractures have a long-lasting negative effect on HRQL up to 12 months after hip fracture. However, HE and/or 2000 IU vitamin D per day may help prevent a further decline in HRQL after the first 6 months following the acute hip fracture event.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1007/s11136-019-02100-4
- PMID 30739288
- Persistent URL
- https://sonar.ch/global/documents/30105
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