Journal article
Idiopathic oedema with increased cytokine production: a pathogenetic link?
- Hoffmann U Department of Internal Medicine, University Hospital, Zurich, Switzerland.
- Fontana A
- Steurer J
- Bollinger A
- 1999-03-30
Published in:
- Journal of internal medicine. - 1998
Adult
Cytokines
Edema
Female
Humans
Interferon-gamma
Interleukin-2
Male
Middle Aged
Receptors, Interleukin-2
Tumor Necrosis Factor-alpha
English
We describe four patients with idiopathic oedema and elevated cytokines. All patients shared increased serum concentrations of soluble interleukin-2 receptors (sIL-2R). In three patients tumour necrosis factor alpha (TNF-alpha), gamma interferon (IFN-gamma) and interleukin-2 (IL-2) were transiently elevated. There was no evidence for an underlying disease. Based on experimental and clinical data it is hypothesized that oedema formation in our patients is the consequence of cytokine induced alteration of endothelial cells.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1046/j.1365-2796.1998.00326.x
- PMID 10095806
- Persistent URL
- https://sonar.ch/global/documents/30983
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