Non-IgE-mediated gastrointestinal food allergies.

Biermé P; Nowak-Wegrzyn A; Caubet JC

doi:10.1097/MOP.0000000000000554

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Journal article

Non-IgE-mediated gastrointestinal food allergies.

Biermé P aDivision of Pediatric Allergy, Department of Pediatrics, University Hospitals of Geneva, Geneva, Switzerland bPediatric Allergy Division, Hôpital Femme-Mère-Enfant, Université de Lyon Est, Lyon, France cDivision of Pediatric Allergy, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Nowak-Wegrzyn A
Caubet JC

2017-09-23

Published in:

Current opinion in pediatrics. - 2017

English PURPOSE OF REVIEW
We focus on recent advances regarding the epidemiology, physiopathology, diagnosis and managements of non-IgE-mediated gastrointestinal food allergies (non-IgE-GI-FAs), particularly food protein-induced enterocolitis syndrome (FPIES).

RECENT FINDINGS
The first international FPIES diagnostic and management guidelines have been recently published. Although FPIES largely remains a diagnosis of exclusion, it may be more prevalent than previously thought. Ondansetron has emerged as a major tool for the treatment of FPIES acute reactions. Recent data also suggest an important role for innate immune cells in FPIES pathogenesis.

SUMMARY
Despite major advances in the diagnosis and management of non-IgE-GI-FAs, particularly FPIES, the lack of specific diagnostic tests and biomarkers to guide clinical management remains challenging.

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