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Evolution, Composition, Assembly, and Function of the Conoid in Apicomplexa.
Journal article

Evolution, Composition, Assembly, and Function of the Conoid in Apicomplexa.

  • Dos Santos Pacheco N Department of Microbiology and Molecular Medicine, CMU, University of Geneva, Geneva, Switzerland.
  • Tosetti N Department of Microbiology and Molecular Medicine, CMU, University of Geneva, Geneva, Switzerland.
  • Koreny L Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK.
  • Waller RF Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK. Electronic address: rfw26@cam.ac.uk.
  • Soldati-Favre D Department of Microbiology and Molecular Medicine, CMU, University of Geneva, Geneva, Switzerland. Electronic address: Dominique.Soldati-Favre@unige.ch.
  • 2020-06-04
Published in:
  • Trends in parasitology. - 2020
Apicomplexa
Toxoplasma gondii
apical complex
apical polar ring
conoid
microtubules
Apicomplexa
Biological Evolution
Organelles
Protozoan Proteins
Toxoplasma
English The phylum Apicomplexa has been defined by the presence of the apical complex, a structure composed of secretory organelles and specific cytoskeletal elements. A conspicuous feature of the apical complex in many apicomplexans is the conoid, a hollow tapered barrel structure composed of tubulin fibers. In Toxoplasma gondii, the apical complex is a central site of convergence for calcium-related and lipid-mediated signaling pathways that coordinate conoid protrusion, microneme secretion, and actin polymerization, to initiate gliding motility. Through cutting-edge technologies, great progress has recently been made in discovering the structural subcomponents and proteins implicated in the biogenesis and stability of the apical complex and, in turn, these discoveries have shed new light on the function and evolution of this definitive structure.
Language
  • English
Open access status
closed
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Persistent URL
https://sonar.ch/global/documents/34436
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