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Organoids to model liver disease.

  • Nuciforo S Department of Biomedicine, University Hospital Basel, University of Basel, CH-4031 Basel, Switzerland.
  • Heim MH Department of Biomedicine, University Hospital Basel, University of Basel, CH-4031 Basel, Switzerland.
  • 2020-11-26
Published in:
  • JHEP reports : innovation in hepatology. - 2021
3D cultures
A1AT, alpha-1 antitrypsin
ALD, alcohol-related liver disease
CCA, cholangiocarcinoma
CFTR, cystic fibrosis transmembrane conductance regulator
CHC, combined hepato-cholangiocarcinoma
CLD, chronic liver disease
CTLN1, citrullinemia type 1
Chol-orgs, cholangiocyte organoids
Disease modelling
EGF, epidermal growth factor
ER, endoplasmic reticulum
ESCs, embryonic stem cells
FFAs, free fatty acids
HCC, hepatocellular carcinoma
HUVEC, human umbilical vein endothelial cells
Hep-orgs, hepatocyte organoids
IL-, interleukin-
Liver disease
MSC, mesenchymal stem cell
NAFLD, non-alcoholic fatty liver disease
Organoids
PDO, patient-derived organoid
PDX, patient-derived xenograft
PHH, primary human hepatocyte
PSC, primary sclerosing cholangitis
Personalised medicine
Preclinical models
iPSC, induced pluripotent stem cell
English The organoid model represents a major breakthrough in cell biology that has revolutionised biomedical research. Organoids are 3D physiological in vitro structures that recapitulate morphological and functional features of in vivo tissues and offer significant advantages over traditional cell culture methods. Liver organoids are of particular interest because of the pleiotropy of functions exerted by the human liver, their utility to model different liver diseases, and their potential application as cell-based therapies in regenerative medicine. Moreover, because they can be derived from patient tissues, organoid models offer new perspectives in personalised medicine and drug discovery. In this review, we discuss the current liver organoid models for the study of liver disease.
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  • English
Open access status
gold
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Persistent URL
https://sonar.ch/global/documents/35406
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