Back
Full-text
Journal article

Epilepsy and Adult Neurogenesis.

  • Jessberger S Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland.
  • Parent JM Department of Neurology, University of Michigan Medical Center and VA Ann Arbor Healthcare System, Ann Arbor, Michigan 48109.
  • 2015-11-11
Published in:
  • Cold Spring Harbor perspectives in biology. - 2015
Animals
Cell Movement
Cell Proliferation
Epilepsy, Temporal Lobe
Hippocampus
Humans
Models, Biological
Neural Stem Cells
Neurogenesis
Rats
Seizures
English Seizure activity in the hippocampal region strongly affects stem cell-associated plasticity in the adult dentate gyrus. Here, we describe how seizures in rodent models of mesial temporal lobe epilepsy (mTLE) affect multiple steps in the developmental course from the dividing neural stem cell to the migrating and integrating newborn neuron. Furthermore, we discuss recent evidence indicating either that seizure-induced aberrant neurogenesis may contribute to the epileptic disease process or that altered neurogenesis after seizures may represent an attempt of the injured brain to repair itself. Last, we describe how dysfunction of adult neurogenesis caused by chronic seizures may play an important role in the cognitive comorbidities associated with mTLE.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://sonar.ch/global/documents/35685
Statistics
Document views: 52 File downloads:
  • Full-text: 0