MR Fingerprinting and ADC Mapping for Characterization of Lesions in the Transition Zone of the Prostate Gland.

Panda A; Obmann VC; Lo WC; Margevicius S; Jiang Y; Schluchter M; Patel IJ; Nakamoto D; Badve C; Griswold MA; Jaeger I; Ponsky LE; Gulani V

doi:10.1148/radiol.2019181705

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MR Fingerprinting and ADC Mapping for Characterization of Lesions in the Transition Zone of the Prostate Gland.

Panda A From the Department of Radiology, Mayo Clinic, Rochester, Minn (A.P.); Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (V.C.O.); Departments of Biomedical Engineering (W.C.L., M.A.G.), Epidemiology and Biostatistics (S.M., M.S.), and Radiology (Y.J., C.B., M.A.G., V.G.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, University of Michigan, UH B1 G503, 1500 E. Medical Center Drive, SPC 5030, Ann Arbor, MI 48109-5030 (Y.J., V.G.); Department of Radiology, Mayo Clinic, Phoenix, Az (I.J.P.); Departments of Radiology (I.J.P., D.N., C.B., M.A.G.) and Urology (I.J., L.E.P.), University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Obmann VC From the Department of Radiology, Mayo Clinic, Rochester, Minn (A.P.); Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (V.C.O.); Departments of Biomedical Engineering (W.C.L., M.A.G.), Epidemiology and Biostatistics (S.M., M.S.), and Radiology (Y.J., C.B., M.A.G., V.G.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, University of Michigan, UH B1 G503, 1500 E. Medical Center Drive, SPC 5030, Ann Arbor, MI 48109-5030 (Y.J., V.G.); Department of Radiology, Mayo Clinic, Phoenix, Az (I.J.P.); Departments of Radiology (I.J.P., D.N., C.B., M.A.G.) and Urology (I.J., L.E.P.), University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Lo WC From the Department of Radiology, Mayo Clinic, Rochester, Minn (A.P.); Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (V.C.O.); Departments of Biomedical Engineering (W.C.L., M.A.G.), Epidemiology and Biostatistics (S.M., M.S.), and Radiology (Y.J., C.B., M.A.G., V.G.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, University of Michigan, UH B1 G503, 1500 E. Medical Center Drive, SPC 5030, Ann Arbor, MI 48109-5030 (Y.J., V.G.); Department of Radiology, Mayo Clinic, Phoenix, Az (I.J.P.); Departments of Radiology (I.J.P., D.N., C.B., M.A.G.) and Urology (I.J., L.E.P.), University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Margevicius S From the Department of Radiology, Mayo Clinic, Rochester, Minn (A.P.); Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (V.C.O.); Departments of Biomedical Engineering (W.C.L., M.A.G.), Epidemiology and Biostatistics (S.M., M.S.), and Radiology (Y.J., C.B., M.A.G., V.G.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, University of Michigan, UH B1 G503, 1500 E. Medical Center Drive, SPC 5030, Ann Arbor, MI 48109-5030 (Y.J., V.G.); Department of Radiology, Mayo Clinic, Phoenix, Az (I.J.P.); Departments of Radiology (I.J.P., D.N., C.B., M.A.G.) and Urology (I.J., L.E.P.), University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Jiang Y From the Department of Radiology, Mayo Clinic, Rochester, Minn (A.P.); Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (V.C.O.); Departments of Biomedical Engineering (W.C.L., M.A.G.), Epidemiology and Biostatistics (S.M., M.S.), and Radiology (Y.J., C.B., M.A.G., V.G.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, University of Michigan, UH B1 G503, 1500 E. Medical Center Drive, SPC 5030, Ann Arbor, MI 48109-5030 (Y.J., V.G.); Department of Radiology, Mayo Clinic, Phoenix, Az (I.J.P.); Departments of Radiology (I.J.P., D.N., C.B., M.A.G.) and Urology (I.J., L.E.P.), University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Schluchter M From the Department of Radiology, Mayo Clinic, Rochester, Minn (A.P.); Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (V.C.O.); Departments of Biomedical Engineering (W.C.L., M.A.G.), Epidemiology and Biostatistics (S.M., M.S.), and Radiology (Y.J., C.B., M.A.G., V.G.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, University of Michigan, UH B1 G503, 1500 E. Medical Center Drive, SPC 5030, Ann Arbor, MI 48109-5030 (Y.J., V.G.); Department of Radiology, Mayo Clinic, Phoenix, Az (I.J.P.); Departments of Radiology (I.J.P., D.N., C.B., M.A.G.) and Urology (I.J., L.E.P.), University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Patel IJ From the Department of Radiology, Mayo Clinic, Rochester, Minn (A.P.); Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (V.C.O.); Departments of Biomedical Engineering (W.C.L., M.A.G.), Epidemiology and Biostatistics (S.M., M.S.), and Radiology (Y.J., C.B., M.A.G., V.G.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, University of Michigan, UH B1 G503, 1500 E. Medical Center Drive, SPC 5030, Ann Arbor, MI 48109-5030 (Y.J., V.G.); Department of Radiology, Mayo Clinic, Phoenix, Az (I.J.P.); Departments of Radiology (I.J.P., D.N., C.B., M.A.G.) and Urology (I.J., L.E.P.), University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Nakamoto D From the Department of Radiology, Mayo Clinic, Rochester, Minn (A.P.); Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (V.C.O.); Departments of Biomedical Engineering (W.C.L., M.A.G.), Epidemiology and Biostatistics (S.M., M.S.), and Radiology (Y.J., C.B., M.A.G., V.G.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, University of Michigan, UH B1 G503, 1500 E. Medical Center Drive, SPC 5030, Ann Arbor, MI 48109-5030 (Y.J., V.G.); Department of Radiology, Mayo Clinic, Phoenix, Az (I.J.P.); Departments of Radiology (I.J.P., D.N., C.B., M.A.G.) and Urology (I.J., L.E.P.), University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Badve C From the Department of Radiology, Mayo Clinic, Rochester, Minn (A.P.); Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (V.C.O.); Departments of Biomedical Engineering (W.C.L., M.A.G.), Epidemiology and Biostatistics (S.M., M.S.), and Radiology (Y.J., C.B., M.A.G., V.G.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, University of Michigan, UH B1 G503, 1500 E. Medical Center Drive, SPC 5030, Ann Arbor, MI 48109-5030 (Y.J., V.G.); Department of Radiology, Mayo Clinic, Phoenix, Az (I.J.P.); Departments of Radiology (I.J.P., D.N., C.B., M.A.G.) and Urology (I.J., L.E.P.), University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Griswold MA From the Department of Radiology, Mayo Clinic, Rochester, Minn (A.P.); Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (V.C.O.); Departments of Biomedical Engineering (W.C.L., M.A.G.), Epidemiology and Biostatistics (S.M., M.S.), and Radiology (Y.J., C.B., M.A.G., V.G.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, University of Michigan, UH B1 G503, 1500 E. Medical Center Drive, SPC 5030, Ann Arbor, MI 48109-5030 (Y.J., V.G.); Department of Radiology, Mayo Clinic, Phoenix, Az (I.J.P.); Departments of Radiology (I.J.P., D.N., C.B., M.A.G.) and Urology (I.J., L.E.P.), University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Jaeger I From the Department of Radiology, Mayo Clinic, Rochester, Minn (A.P.); Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (V.C.O.); Departments of Biomedical Engineering (W.C.L., M.A.G.), Epidemiology and Biostatistics (S.M., M.S.), and Radiology (Y.J., C.B., M.A.G., V.G.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, University of Michigan, UH B1 G503, 1500 E. Medical Center Drive, SPC 5030, Ann Arbor, MI 48109-5030 (Y.J., V.G.); Department of Radiology, Mayo Clinic, Phoenix, Az (I.J.P.); Departments of Radiology (I.J.P., D.N., C.B., M.A.G.) and Urology (I.J., L.E.P.), University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Ponsky LE From the Department of Radiology, Mayo Clinic, Rochester, Minn (A.P.); Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (V.C.O.); Departments of Biomedical Engineering (W.C.L., M.A.G.), Epidemiology and Biostatistics (S.M., M.S.), and Radiology (Y.J., C.B., M.A.G., V.G.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, University of Michigan, UH B1 G503, 1500 E. Medical Center Drive, SPC 5030, Ann Arbor, MI 48109-5030 (Y.J., V.G.); Department of Radiology, Mayo Clinic, Phoenix, Az (I.J.P.); Departments of Radiology (I.J.P., D.N., C.B., M.A.G.) and Urology (I.J., L.E.P.), University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Gulani V From the Department of Radiology, Mayo Clinic, Rochester, Minn (A.P.); Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland (V.C.O.); Departments of Biomedical Engineering (W.C.L., M.A.G.), Epidemiology and Biostatistics (S.M., M.S.), and Radiology (Y.J., C.B., M.A.G., V.G.), Case Western Reserve University, Cleveland, Ohio; Department of Radiology, University of Michigan, UH B1 G503, 1500 E. Medical Center Drive, SPC 5030, Ann Arbor, MI 48109-5030 (Y.J., V.G.); Department of Radiology, Mayo Clinic, Phoenix, Az (I.J.P.); Departments of Radiology (I.J.P., D.N., C.B., M.A.G.) and Urology (I.J., L.E.P.), University Hospitals Cleveland Medical Center, Cleveland, Ohio.

2019-07-24

Published in:

Radiology. - 2019

English BackgroundPreliminary studies have shown that MR fingerprinting-based relaxometry combined with apparent diffusion coefficient (ADC) mapping can be used to differentiate normal peripheral zone from prostate cancer and prostatitis. The utility of relaxometry and ADC mapping for the transition zone (TZ) is unknown.PurposeTo evaluate the utility of MR fingerprinting combined with ADC mapping for characterizing TZ lesions.Materials and MethodsTZ lesions that were suspicious for cancer in men who underwent MRI with T2-weighted imaging and ADC mapping (b values, 50-1400 sec/mm2), MR fingerprinting with steady-state free precession, and targeted biopsy (60 in-gantry and 15 cognitive targeting) between September 2014 and August 2018 in a single university hospital were retrospectively analyzed. Two radiologists blinded to Prostate Imaging Reporting and Data System (PI-RADS) scores and pathologic diagnosis drew regions of interest on cancer-suspicious lesions and contralateral visually normal TZs (NTZs) on MR fingerprinting and ADC maps. Linear mixed models compared two-reader means of T1, T2, and ADC. Generalized estimating equations logistic regression analysis was used to evaluate both MR fingerprinting and ADC in differentiating NTZ, cancers and noncancers, clinically significant (Gleason score ≥ 7) cancers from clinically insignificant lesions (noncancers and Gleason 6 cancers), and characterizing PI-RADS version 2 category 3 lesions.ResultsIn 67 men (mean age, 66 years ± 8 [standard deviation]) with 75 lesions, targeted biopsy revealed 37 cancers (six PI-RADS category 3 cancers and 31 PI-RADS category 4 or 5 cancers) and 38 noncancers (31 PI-RADS category 3 lesions and seven PI-RADS category 4 or 5 lesions). The T1, T2, and ADC of NTZ (1800 msec ± 150, 65 msec ± 22, and [1.13 ± 0.19] × 10-3 mm2/sec, respectively) were higher than those in cancers (1450 msec ± 110, 36 msec ± 11, and [0.57 ± 0.13] × 10-3 mm2/sec, respectively; P < .001 for all). The T1, T2, and ADC in cancers were lower than those in noncancers (1620 msec ± 120, 47 msec ± 16, and [0.82 ± 0.13] × 10-3 mm2/sec, respectively; P = .001 for T1 and ADC and P = .03 for T2). The area under the receiver operating characteristic curve (AUC) for T1 plus ADC was 0.94 for separation. T1 and ADC in clinically significant cancers (1440 msec ± 140 and [0.58 ± 0.14] × 10-3 mm2/sec, respectively) were lower than those in clinically insignificant lesions (1580 msec ± 120 and [0.75 ± 0.17] × 10-3 mm2/sec, respectively; P = .001 for all). The AUC for T1 plus ADC was 0.81 for separation. Within PI-RADS category 3 lesions, T1 and ADC of cancers (1430 msec ± 220 and [0.60 ± 0.17] × 10-3 mm2/sec, respectively) were lower than those of noncancers (1630 msec ± 120 and [0.81 ± 0.13] × 10-3 mm2/sec, respectively; P = .006 for T1 and P = .004 for ADC). The AUC for T1 was 0.79 for differentiating category 3 lesions.ConclusionMR fingerprinting-based relaxometry combined with apparent diffusion coefficient mapping may improve transition zone lesion characterization.© RSNA, 2019Online supplemental material is available for this article.

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