Journal article
Bowen disease of the nail unit: a retrospective study of 12 cases and their association with human papillomaviruses.
- Perruchoud DL Department of Dermatology, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland.
- Varonier C Department of Dermatology, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland.
- Haneke E Department of Dermatology, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland.
- Hunger RE Department of Dermatology, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland.
- Beltraminelli H Department of Dermatology, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland.
- Borradori L Department of Dermatology, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland.
- Ehnis Pérez A Department of Dermatology, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland.
- 2016-07-14
Published in:
- Journal of the European Academy of Dermatology and Venereology : JEADV. - 2016
Adult
Aged
Bowen's Disease
Female
Humans
Male
Middle Aged
Nail Diseases
Papillomaviridae
Retrospective Studies
English
BACKGROUND
Bowen disease is the most frequent nail malignancy, usually seen as a verrucous plaque of the nail in men.
OBJECTIVE
To characterize the affected patient population, the clinical manifestations, the diagnostic delay and diagnostic steps, and presence of human papilloma virus (HPV) infection.
METHODS
We retrospectively evaluated all cases of Bowen disease of the nail unit over a period of 9 years. Data were obtained from our electronic database. Human papilloma virus genotype was assessed in biopsy specimens by polymerase chain reaction (PCR) sequencing.
RESULTS
We identified 12 cases of Bowen disease of the nail unit in 10 patients. Mean age at onset was 52 years, with a male predominance of 90%. The thumb and middle finger were the most frequently affected (66%). Fifty percent of the lesions presented as periungual and subungual verrucous tumours. Patients sought medical evaluation after a mean delay of 5.7 years; histopathological diagnosis was made after a mean delay of 3.2 years. HPV infection was identified in 75% of the cases.
CONCLUSIONS
Any recently appeared verrucous lesion of the nail unit in men above the age of 40 years should raise the suspicion of Bowen disease and lead to further histopathological diagnostic procedures.
Bowen disease is the most frequent nail malignancy, usually seen as a verrucous plaque of the nail in men.
OBJECTIVE
To characterize the affected patient population, the clinical manifestations, the diagnostic delay and diagnostic steps, and presence of human papilloma virus (HPV) infection.
METHODS
We retrospectively evaluated all cases of Bowen disease of the nail unit over a period of 9 years. Data were obtained from our electronic database. Human papilloma virus genotype was assessed in biopsy specimens by polymerase chain reaction (PCR) sequencing.
RESULTS
We identified 12 cases of Bowen disease of the nail unit in 10 patients. Mean age at onset was 52 years, with a male predominance of 90%. The thumb and middle finger were the most frequently affected (66%). Fifty percent of the lesions presented as periungual and subungual verrucous tumours. Patients sought medical evaluation after a mean delay of 5.7 years; histopathological diagnosis was made after a mean delay of 3.2 years. HPV infection was identified in 75% of the cases.
CONCLUSIONS
Any recently appeared verrucous lesion of the nail unit in men above the age of 40 years should raise the suspicion of Bowen disease and lead to further histopathological diagnostic procedures.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1111/jdv.13654
- PMID 27405962
- Persistent URL
- https://sonar.ch/global/documents/47
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