Back
Defective DNA repair in a large family having a high occurrence of cancer.
Journal article

Defective DNA repair in a large family having a high occurrence of cancer.

  • Kovacs E Department of Research, University Clinics, Kantonsspital, Basel, Switzerland.
  • Langemann H
  • 1988-01-01
Published in:
  • Oncology. - 1988
Adult
Aged
Aged, 80 and over
DNA
DNA Repair
Female
Humans
Lymphocytes
Male
Middle Aged
Neoplasms
Pedigree
Ultraviolet Rays
English DNA repair synthesis induced by UV light was investigated in unstimulated lymphocytes of 18 healthy members of a large family. Three generations were included: the mother (82 years), her 11 surviving adult children (34-52 years) and 6 of her grandchildren (20-23 years). In the first generation on the paternal side the father and 4 of his 7 siblings had suffered from cancer, in the second generation 1 son and 1 daughter. [3H]-Thymidine incorporation was taken as the parameter for the DNA repair synthesis. DNA repair synthesis was reduced in 14 out of 18 family members; 1 in the first generation, 7 in the second generation, and all 6 in the third generation. In comparison only 14 out of 92 aged-matched controls showed a defective DNA repair. Results provide further evidence that first-degree relatives of cancer patients have an increased incidence of defective DNA repair.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/47076
Statistics
Document views: 17 File downloads: