Clinical and Histopathologic Ocular Findings in Disseminated Mycobacterium chimaera Infection after Cardiothoracic Surgery.
- Zweifel SA Department of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. Electronic address: sandrine.zweifel@usz.ch.
- Mihic-Probst D Institute of Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
- Curcio CA Department of Ophthalmology, University of Alabama School of Medicine, Birmingham, Alabama.
- Barthelmes D Department of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; The Save Sight Institute, The University of Sydney, Sydney, Australia.
- Thielken A Institute of Pathology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
- Keller PM Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland; Swiss National Center for Mycobacteria, University of Zurich, Institute of Medical Microbiology, Zurich, Switzerland.
- Hasse B Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
- Böni C Department of Ophthalmology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
- 2016-11-23
Published in:
- Ophthalmology. - 2017
Aged
Cardiopulmonary Bypass
Chimera
Endocarditis, Bacterial
Eye
Eye Diseases
Eye Infections, Bacterial
Female
Fluorescein Angiography
Humans
Immunohistochemistry
Male
Middle Aged
Mycobacterium
Mycobacterium Infections
Postoperative Complications
Tomography, Optical Coherence
Visual Acuity
English
PURPOSE
To investigate and characterize clinical and histopathologic ocular findings in patients with disseminated infection with Mycobacterium chimaera, a slow-growing nontuberculous mycobacterium (NTM), subsequent to cardiothoracic surgery.
DESIGN
Observational case series.
PARTICIPANTS
Five white patients (10 eyes).
METHODS
Analysis of clinical ocular findings, including visual acuity, slit-lamp biomicroscopy, spectral-domain optical coherence tomography (SD OCT), fundus autofluorescence (FAF), and fluorescein angiography/indocyanine green (ICG) angiography findings, of patients with a disseminated M. chimaera infection. Biomicroscopic and multimodal imaging findings were compared with the histopathology of 1 patient.
MAIN OUTCOME MEASURES
Clinical and histopathologic ocular findings of M. chimaera.
RESULTS
The mean age of the 5 male patients, diagnosed with endocarditis or aortic graft infection, was 57.8 years. Clinical ocular findings included anterior and intermediate uveitis, optic disc swelling, and white-yellowish choroidal lesions. Multifocal choroidal lesions were observed bilaterally in all patients and were hyperfluorescent on fluorescein angiography, hypofluorescent on ICG angiography, and correlated with choroidal lesions on SD OCT. The extent of choroidal lesions varied from few in 2 patients to widespread miliary lesions in 3 patients leading to localized choroidal thickening with elevation of the overlying retinal layers. Spectral-domain optical coherence tomography through regressing lesions revealed altered outer retinal layers and choroidal hypertransmission. The ocular findings were correlated with the course of the systemic disease. Patients with few choroidal lesions had a favorable outcome, whereas all patients with widespread chorioretinitis died of systemic complications of M. chimaera infection despite long-term targeted antimicrobial therapy. Ocular tissue was obtained from 1 patient at autopsy. Necropsy of 2 eyes of 1 patient revealed prominent granulomatous lymphohistiocytic choroiditis with giant cells.
CONCLUSIONS
M. chimaera infection subsequent to cardiothoracic surgery is a novel entity that has been recently described. It involves multiple organ systems and can cause life-threatening disseminated disease. The ocular manifestations documented using multimodal imaging allow us to use the eye as a window to the systemic infection.
To investigate and characterize clinical and histopathologic ocular findings in patients with disseminated infection with Mycobacterium chimaera, a slow-growing nontuberculous mycobacterium (NTM), subsequent to cardiothoracic surgery.
DESIGN
Observational case series.
PARTICIPANTS
Five white patients (10 eyes).
METHODS
Analysis of clinical ocular findings, including visual acuity, slit-lamp biomicroscopy, spectral-domain optical coherence tomography (SD OCT), fundus autofluorescence (FAF), and fluorescein angiography/indocyanine green (ICG) angiography findings, of patients with a disseminated M. chimaera infection. Biomicroscopic and multimodal imaging findings were compared with the histopathology of 1 patient.
MAIN OUTCOME MEASURES
Clinical and histopathologic ocular findings of M. chimaera.
RESULTS
The mean age of the 5 male patients, diagnosed with endocarditis or aortic graft infection, was 57.8 years. Clinical ocular findings included anterior and intermediate uveitis, optic disc swelling, and white-yellowish choroidal lesions. Multifocal choroidal lesions were observed bilaterally in all patients and were hyperfluorescent on fluorescein angiography, hypofluorescent on ICG angiography, and correlated with choroidal lesions on SD OCT. The extent of choroidal lesions varied from few in 2 patients to widespread miliary lesions in 3 patients leading to localized choroidal thickening with elevation of the overlying retinal layers. Spectral-domain optical coherence tomography through regressing lesions revealed altered outer retinal layers and choroidal hypertransmission. The ocular findings were correlated with the course of the systemic disease. Patients with few choroidal lesions had a favorable outcome, whereas all patients with widespread chorioretinitis died of systemic complications of M. chimaera infection despite long-term targeted antimicrobial therapy. Ocular tissue was obtained from 1 patient at autopsy. Necropsy of 2 eyes of 1 patient revealed prominent granulomatous lymphohistiocytic choroiditis with giant cells.
CONCLUSIONS
M. chimaera infection subsequent to cardiothoracic surgery is a novel entity that has been recently described. It involves multiple organ systems and can cause life-threatening disseminated disease. The ocular manifestations documented using multimodal imaging allow us to use the eye as a window to the systemic infection.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1016/j.ophtha.2016.09.032
- PMID 27871762
- Persistent URL
- https://sonar.ch/global/documents/47355
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