Journal article
Topical timolol maleate might adversely affect serum lipoproteins.
- Safran AB Department of Ophthalmology, Geneva University Hospital, Switzerland.
- Simona F
- Sansonetti A
- Pometta D
- James R
- 1993-04-01
Published in:
- International ophthalmology. - 1993
Administration, Topical
Adult
Aged
Aged, 80 and over
Glaucoma
Humans
Hyperlipoproteinemias
Lipoproteins
Middle Aged
Ophthalmic Solutions
Timolol
English
Conflicting observations have been reported about the effects of topically administered timolol maleate on serum lipoproteins. We therefore considered this issue in a series of eight glaucoma patients receiving timolol maleate. Cholesterol and triglycerides were measured in plasma and in low-density lipoproteins (LDL), and high-density lipoproteins (HDL), both before and following three months of treatment. Following the treatment, the mean atherogenic index was increased from 2.72 to 3.38 (p = 0.012). This suggests that the atherogenic index should be determined before and during timolol maleate treatment in high-risk cardiovascular patients.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1007/bf00942785
- PMID 8407117
- Persistent URL
- https://sonar.ch/global/documents/5135
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