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Skin prick test and basophil reactivity to cetuximab in patients with IgE to alpha-gal and allergy to red meat.
Journal article

Skin prick test and basophil reactivity to cetuximab in patients with IgE to alpha-gal and allergy to red meat.

  • 2013-12-31
Published in:
  • Allergy. - 2014
alpha-gal
anaphylaxis
cetuximab
food allergy
Aged
Allergens
Anaphylaxis
Antibodies, Monoclonal, Humanized
Basophils
Cetuximab
Drug Hypersensitivity
Female
Food Hypersensitivity
Humans
Immunoglobulin E
Male
Meat Products
Middle Aged
Skin Tests
English Severe hypersensitivity reactions to red meat with delay of several hours in patients with IgE to alpha-gal (galactose-alpha-1,3-galactose) have been reported. The diagnosis of meat allergy is difficult, because of the limited sensitivity of skin prick tests and specific IgE tests to meat extracts. These circumstances have been explained by the delayed expression of alpha-gal due to digestive processes. Because of the low sensitivity of skin prick tests to meat, we studied the possibility to perform skin prick tests with cetuximab, which carries the alpha-gal epitope. Skin prick and intradermal tests with cetuximab were clearly positive in 2 of 2 patients. As a further diagnostic step, we performed basophil activation tests with cetuximab. Skin prick tests and basophil activation test using cetuximab may be a more sensitive alternative in patients with an assumed allergy to meat.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/5768
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