The cellular protein TIP47 restricts Respirovirus multiplication leading to decreased virus particle production.

Bampi C; Grenet AS; Caignard G; Vidalain PO; Roux L

doi:10.1016/j.virusres.2013.01.006

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Journal article

The cellular protein TIP47 restricts Respirovirus multiplication leading to decreased virus particle production.

Bampi C Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Grenet AS
Caignard G
Vidalain PO
Roux L

2013-01-26

Published in:

Virus research. - 2013

English The cellular tail-interacting 47-kDa protein (TIP47) acts positively on HIV-1 and vaccinia virus production. We show here that TIP47, in contrast, acts as a restriction factor for Sendai virus production. This conclusion is supported by the occurrence of increased or decreased virus production upon its suppression or overexpression, respectively. Pulse-chase metabolic labeling of viral proteins under conditions of TIP47 suppression reveals an increased rate of viral protein synthesis followed by increased incorporation of viral proteins into virus particles. TIP47 is here described for the first time as a viral restriction factor that acts by limiting viral protein synthesis.

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