Journal article
Anti-IgE in allergic sensitization.
- Stadler BM Institute of Immunology and Allergology, University of Bern, Switzerland.
- Rudolf MP
- Zürcher AW
- Miescher S
- Vogel M
- 1996-04-01
Published in:
- Immunology and cell biology. - 1996
Animals
Antibodies, Monoclonal
Autoantibodies
Cloning, Molecular
Humans
Hypersensitivity, Immediate
Immunization
Immunoglobulin E
Vaccines
English
Anti-IgE autoantibodies exist predominantly in the sera of patients with atopic disease. For some time such anti-IgE autoantibodies have been considered a phenomenon that may not be of clinical importance. The cloning of such anti-IgE autoantibodies has eliminated doubts of whether these antibodies exist, but it is still unclear whether such autoantibodies play a pathophysiological role. However, there are ongoing clinical trials that use humanized anti-IgE antibodies for passive immunization of atopic individuals. While this approach may not definitely clarify the role of anti-IgE autoantibodies, it will nevertheless clarify the role of IgE.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1038/icb.1996.27
- PMID 8724009
- Persistent URL
- https://sonar.ch/global/documents/63669
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