Journal article
Extensive white-matter changes in case of adult polyglucosan body disease.
- Berkhoff M Department of Neurology, Inselspital, Berne, Switzerland.
- Weis J
- Schroth G
- Sturzenegger M
- 2001-04-18
Published in:
- Neuroradiology. - 2001
Ataxia
Biopsy
Brain Diseases
Dementia
Diagnosis, Differential
Disease Progression
Glucans
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Skin
English
Extensive white matter signal changes were observed on T2-weighted images of a 49-year-old man. He presented with a slowly progressive gait disorder, and finally developed severe dementia. Extensive metabolic and infectious investigations failed to disclose the underlying cause during life. Autopsy revealed adult polyglucosan body disease. We discuss MRI findings likely to permit this diagnosis if combined with clinical findings and nerve or skin biopsy.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1007/s002340000425
- PMID 11305757
- Persistent URL
- https://sonar.ch/global/documents/6374
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