Single nucleotide polymorphisms as a prerequisite for autoantigens.
- Stadler MB Institute of Immunology, University of Bern, Bern, Switzerland. stadler@mit.edu
- Arnold D
- Frieden S
- Luginbühl S
- Stadler BM
- 2005-01-04
Published in:
- European journal of immunology. - 2005
Amino Acid Sequence
Autoantigens
Autoimmune Diseases
Autoimmunity
Chromosome Mapping
Databases, Genetic
Epitopes
Humans
Molecular Sequence Data
Multigene Family
Polymorphism, Single Nucleotide
Self Tolerance
English
It is still elusive why certain self proteins induce an autoimmune response. One immunological hypothesis is that only modified or altered self-proteins may become a target. Thus, we asked whether such alterations may actually be genetic polymorphisms that can be revealed by analyzing sequence variability in the known human autoantigens. Indeed, we found autoantigens to contain significantly more single nucleotide polymorphisms (SNP) than other human genes do. Our finding may offer an explanation for autoimmune responses through allogeneic exposure. Besides other contributing factors in autoimmunity, SNP may represent an essential prerequisite for the primary induction of an autoimmune response.
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1002/eji.200425481
- PMID 15627977
- Persistent URL
- https://sonar.ch/global/documents/6496
Statistics
Document views: 30
File downloads:
- Full-text: 0