Randomised in situ trial on the effect of milk and CPP-ACP on dental erosion.
- Wiegand A Department of Preventive Dentistry, Periodontology and Cariology, University of Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany. Electronic address: annette.wiegand@med.uni-goettingen.de.
- Attin T Department of Preventive Dentistry, Periodontology and Cariology, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland.
- 2014-07-20
Published in:
- Journal of dentistry. - 2014
Calcium
Demineralization
Dentine
Enamel
Fluoride
Phosphate
Adult
Amines
Animals
Cariostatic Agents
Caseins
Cattle
Cross-Over Studies
Dental Enamel
Dentin
Female
Fluorides
Humans
Male
Milk
Mouthwashes
Prospective Studies
Single-Blind Method
Sodium Fluoride
Tin Compounds
Tooth Abrasion
Tooth Erosion
Toothpastes
English
OBJECTIVES
This randomised in situ study aimed to analyse the effect of milk (with or without 5ppm F) and CPP-ACP pastes (with or without 900ppm F) on dental erosion.
METHODS
The study was a seven phase (5 days each) crossover design involving 15 participants wearing intraoral appliances with enamel and dentine specimens. Specimens were extraorally eroded (erosive soft drink, 6×90s/day) and brushed (2×30s/day, 2N) using a non-fluoridated toothpaste (negative control). The test products were milk, milk+5ppm F (twice daily, each 100ml/2min), CPP-ACP paste, CPP-ACP paste+900ppm F (3min/day) or a SnCl2/AmF/NaF mouthrinse (positive control, 30s/day), which were applied immediately after erosion with the appliances in the oral cavity. In an additional group, a fluoridated toothpaste was used without any additional test product. Tissue loss was determined profilometrically after 5 days and statistically analysed by linear mixed models methodologies (p<0.05).
RESULTS
Compared with the negative control (non-fluoridated toothpaste only, enamel: 2.2±1.3μm; dentine: 3.8±2.2μm), enamel and dentine loss was significantly reduced by the use of fluoridated toothpaste (enamel: 1.1±1.0μm; dentine: 2.4±1.7μm) and the SnCl2/AmF/NaF mouthrinse (1.5±1.5μm; dentine: 1.8±1.9μm).
CONCLUSIONS
Milk and CPP-ACP were not effective in reducing enamel and dentine loss significantly, independently of the presence of fluoride.
CLINICAL SIGNIFICANCE
Enamel and dentine erosion were significantly reduced by the use of a fluoridated toothpaste or a SnCl2/AmF/NaF mouthrinse, but not by milk or CPP-ACP under the conditions of the present study.
CLINICAL TRIALS REGISTRATION
NCT01566357.
This randomised in situ study aimed to analyse the effect of milk (with or without 5ppm F) and CPP-ACP pastes (with or without 900ppm F) on dental erosion.
METHODS
The study was a seven phase (5 days each) crossover design involving 15 participants wearing intraoral appliances with enamel and dentine specimens. Specimens were extraorally eroded (erosive soft drink, 6×90s/day) and brushed (2×30s/day, 2N) using a non-fluoridated toothpaste (negative control). The test products were milk, milk+5ppm F (twice daily, each 100ml/2min), CPP-ACP paste, CPP-ACP paste+900ppm F (3min/day) or a SnCl2/AmF/NaF mouthrinse (positive control, 30s/day), which were applied immediately after erosion with the appliances in the oral cavity. In an additional group, a fluoridated toothpaste was used without any additional test product. Tissue loss was determined profilometrically after 5 days and statistically analysed by linear mixed models methodologies (p<0.05).
RESULTS
Compared with the negative control (non-fluoridated toothpaste only, enamel: 2.2±1.3μm; dentine: 3.8±2.2μm), enamel and dentine loss was significantly reduced by the use of fluoridated toothpaste (enamel: 1.1±1.0μm; dentine: 2.4±1.7μm) and the SnCl2/AmF/NaF mouthrinse (1.5±1.5μm; dentine: 1.8±1.9μm).
CONCLUSIONS
Milk and CPP-ACP were not effective in reducing enamel and dentine loss significantly, independently of the presence of fluoride.
CLINICAL SIGNIFICANCE
Enamel and dentine erosion were significantly reduced by the use of a fluoridated toothpaste or a SnCl2/AmF/NaF mouthrinse, but not by milk or CPP-ACP under the conditions of the present study.
CLINICAL TRIALS REGISTRATION
NCT01566357.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1016/j.jdent.2014.07.009
- PMID 25038509
- Persistent URL
- https://sonar.ch/global/documents/66251
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