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Elevated HbA1c is not associated with recurrent venous thromboembolism in the elderly, but with all-cause mortality- the SWEETCO 65+ study.

  • Mathis A DiaMon Institute, Baden-Dättwil, Switzerland.
  • Villiger L DiaMon Institute, Baden-Dättwil, Switzerland.
  • Reiner MF Department of Internal Medicine, Cantonal Hospital of Baden, Baden, Switzerland.
  • Egloff M Department of Internal Medicine, Cantonal Hospital of Baden, Baden, Switzerland.
  • Schmid HR Central Laboratory, Cantonal Hospital of Baden, Baden, Switzerland.
  • Stivala S Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.
  • Limacher A CTU Bern, and Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
  • Mean M Division of General Internal Medicine, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.
  • Aujesky D Division of General Internal Medicine, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.
  • Rodondi N Division of General Internal Medicine, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.
  • Angelillo-Scherrer A Department of Hematology and Central Hematology Laboratory, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.
  • Righini M Division of Angiology and Hemostasis, Geneva University Hospital, Geneva, Switzerland.
  • Staub D Division of Angiology, Basel University Hospital, Basel, Switzerland.
  • Aschwanden M Division of Angiology, Basel University Hospital, Basel, Switzerland.
  • Frauchiger B Department of Internal Medicine, Cantonal Hospital of Frauenfeld, Frauenfeld, Switzerland.
  • Osterwalder J Cantonal Hospital of St. Gallen, St. Gallen, Switzerland.
  • Kucher N Division of Angiology, Zurich University Hospital, Zurich, Switzerland.
  • Matter CM Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.
  • Banyai M Division of Angiology, Cantonal Hospital of Lucerne, Lucerne, Switzerland.
  • Hugli O Emergency Department, Lausanne University Hospital, Lausanne, Switzerland.
  • Beer JH Department of Internal Medicine, Cantonal Hospital of Baden, Baden, Switzerland. hansjuerg.beer@ksb.ch.
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  • 2020-02-14
Published in:
  • Scientific reports. - 2020
Aged
Aged, 80 and over
Biomarkers
Female
Glycated Hemoglobin A
Humans
Male
Mortality
Venous Thromboembolism
English The association of glycated hemoglobin (HbA1c) with venous thromboembolism (VTE) and death in the elderly is unknown. In the SWEETCO 65+ study we analyzed prospectively a Swiss Cohort of Elderly Patients with Venous Thromboembolism (SWITCO 65+). 888 patients were enrolled for the SWEETCO 65+ analysis. HbA1c was determined at baseline and divided into three categories (HbA1c < 5.7%, normal range; 5.7-6.49%, pre-diabetic range; and >6.5%, diabetic range). Median follow-up was 2.5 years. The primary endpoint was recurrent VTE. Secondary endpoints included all-cause mortality and major bleeds. The total prevalence of diabetes was 22.1%. The risk of recurrent VTE was similar in patients with HbA1c with pre-diabetes (adjusted subhazard ratio (aSHR) 1.07 [0.70 to 1.63]) and diabetes (aSHR 0.73 [0.39 to 1.37]) as compared to those with a HbA1c in the normal range. However, a HbA1c ≥ 6.5% (median IQ range 7.0 [6.70;7.60]) was significantly associated with a higher risk of all-cause mortality (adjusted hazard ratio [aHR] 1.83 [1.21 to 2.75]). In summary we found no association between HbA1c and major bleeding. Elevated HbA1c levels are not associated with recurrent VTE but with increased all-cause mortality in an elderly population with acute VTE.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/67127
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